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Most cancer tissues were negative. A few lymphomas, breast cancers and skin cancers displayed distinct nuclear immunoreactivity. Lymphoid cells of tumor stroma were strongly positive.
Moderate to strong cytoplasmic staining with a granular pattern was observed in a few hepatocellular carcinomas and lymphomas. Remaining cancer tissues were in general negative.
GENE INFORMATION
Gene name
ZAP70 (HGNC Symbol)
Synonyms
SRK, STD, ZAP-70
Description
Zeta-chain (TCR) associated protein kinase 70kDa (HGNC Symbol)
Entrez gene summary
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SCAMPI predicted membrane proteins Predicted intracellular proteins Plasma proteins RAS pathway related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins RAS pathway related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)