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ZAP70

GENERAL INFORMATION

Gene name

 ZAP70

Gene description

 Zeta-chain (TCR) associated protein kinase 70kDa

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (appendix, lymph node, spleen)
GTEx:Group enriched (lung, small intestine, spleen)
FANTOM5:Tissue enhanced (appendix, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in subsets of immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA003134 , CAB002625
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, lymph node, spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lung, small intestine, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, tonsil)

GENE INFORMATION

Gene name

 ZAP70 (HGNC Symbol)

Synonyms

 SRK, STD, ZAP-70

Description

 Zeta-chain (TCR) associated protein kinase 70kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q11.2

Chromosome location (bp)

 97713560 - 97739862

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115085 (version 83.38)

Entrez gene

 7535

UniProt

 P43403 (UniProt - Evidence at protein level)

neXtProt

 NX_P43403

Antibodypedia

 ZAP70 antibodies

PROTEIN BROWSER
ZAP70-001
ZAP70-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZAP70-001
ENSP00000264972
ENST00000264972
P43403 [Direct mapping]
Tyrosine-protein kinase ZAP-70
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001772 [immunological synapse]
GO:0001784 [phosphotyrosine binding]
GO:0002250 [adaptive immune response]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006468 [protein phosphorylation]
GO:0006955 [immune response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030154 [cell differentiation]
GO:0030217 [T cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042101 [T cell receptor complex]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0043366 [beta selection]
GO:0045059 [positive thymic T cell selection]
GO:0045060 [negative thymic T cell selection]
GO:0045061 [thymic T cell selection]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045582 [positive regulation of T cell differentiation]
GO:0046638 [positive regulation of alpha-beta T cell differentiation]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0046777 [protein autophosphorylation]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0050852 [T cell receptor signaling pathway]
GO:0070489 [T cell aggregation]
GO:0072678 [T cell migration]
Show all
 619 aa
69.9 kDa 		No 0
ZAP70-008
ENSP00000400475
ENST00000451498
P43403 [Direct mapping]
Tyrosine-protein kinase ZAP-70
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001772 [immunological synapse]
GO:0002250 [adaptive immune response]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006955 [immune response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030154 [cell differentiation]
GO:0030217 [T cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042101 [T cell receptor complex]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0045059 [positive thymic T cell selection]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045582 [positive regulation of T cell differentiation]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0050852 [T cell receptor signaling pathway]
GO:0070489 [T cell aggregation]
GO:0072678 [T cell migration]
Show all
 312 aa
35.6 kDa 		No 0

Contact

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The Human Protein Atlas

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