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NRBP1

GENERAL INFORMATION

Gene name

 NRBP1

Gene description

 Nuclear receptor binding protein 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA029527 , CAB033078
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA029527
CAB033078

GENE INFORMATION

Gene name

 NRBP1 (HGNC Symbol)

Synonyms

 BCON3, MADM, MUDPNP, NRBP

Description

 Nuclear receptor binding protein 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 p23.3

Chromosome location (bp)

 27427790 - 27442259

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115216 (version 83.38)

Entrez gene

 29959

UniProt

 Q9UHY1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHY1

Antibodypedia

 NRBP1 antibodies

PROTEIN BROWSER
NRBP1-001
NRBP1-002
NRBP1-003
NRBP1-006
NRBP1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NRBP1-001
ENSP00000233557
ENST00000233557
Q9UHY1 [Direct mapping]
Nuclear receptor-binding protein
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Enzymes
   Kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005938 [cell cortex]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0010467 [gene expression]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
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 535 aa
59.8 kDa 		No 0
NRBP1-002
ENSP00000369181
ENST00000379852
Q9UHY1 [Direct mapping]
Nuclear receptor-binding protein
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Enzymes
   Kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005938 [cell cortex]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0010467 [gene expression]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0042803 [protein homodimerization activity]
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 535 aa
59.8 kDa 		No 0
NRBP1-003
ENSP00000369192
ENST00000379863
F8W6G1 [Direct mapping]
Nuclear receptor-binding protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 543 aa
60.8 kDa 		No 0
NRBP1-006
ENSP00000403916
ENST00000419281
C9JHZ6 [Direct mapping]
Nuclear receptor-binding protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 155 aa
17.5 kDa 		No 0
NRBP1-007
ENSP00000415406
ENST00000356442
C9JDW7 [Direct mapping]
Nuclear receptor-binding protein
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 82 aa
8.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.