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TACR1

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GENERAL INFORMATION

Gene name

 TACR1

Gene description

 Tachykinin receptor 1

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 TACR1 (HGNC Symbol)

Synonyms

 NK1R, NKIR, SPR, TAC1R

Description

 Tachykinin receptor 1 (HGNC Symbol)

Entrez gene summary

 This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]

Chromosome

 2

Cytoband

 p12

Chromosome location (bp)

 75046463 - 75199700

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115353 (version 83.38)

Entrez gene

 6869

UniProt

 P25103 (UniProt - Evidence at protein level)

neXtProt

 NX_P25103

Antibodypedia

 TACR1 antibodies

PROTEIN BROWSER
TACR1-001
TACR1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TACR1-001
ENSP00000303522
ENST00000305249
P25103 [Direct mapping]
Substance-P receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0002118 [aggressive behavior]
GO:0002526 [acute inflammatory response]
GO:0002687 [positive regulation of leukocyte migration]
GO:0003051 [angiotensin-mediated drinking behavior]
GO:0004930 [G-protein coupled receptor activity]
GO:0004995 [tachykinin receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007217 [tachykinin receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007611 [learning or memory]
GO:0007616 [long-term memory]
GO:0008217 [regulation of blood pressure]
GO:0008306 [associative learning]
GO:0009408 [response to heat]
GO:0009582 [detection of abiotic stimulus]
GO:0009725 [response to hormone]
GO:0009986 [cell surface]
GO:0010193 [response to ozone]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010996 [response to auditory stimulus]
GO:0014070 [response to organic cyclic compound]
GO:0014910 [regulation of smooth muscle cell migration]
GO:0016021 [integral component of membrane]
GO:0016496 [substance P receptor activity]
GO:0030425 [dendrite]
GO:0032224 [positive regulation of synaptic transmission, cholinergic]
GO:0032230 [positive regulation of synaptic transmission, GABAergic]
GO:0032355 [response to estradiol]
GO:0032570 [response to progesterone]
GO:0035094 [response to nicotine]
GO:0035106 [operant conditioning]
GO:0035815 [positive regulation of renal sodium excretion]
GO:0042713 [sperm ejaculation]
GO:0042755 [eating behavior]
GO:0043117 [positive regulation of vascular permeability]
GO:0043278 [response to morphine]
GO:0044297 [cell body]
GO:0045471 [response to ethanol]
GO:0045760 [positive regulation of action potential]
GO:0045777 [positive regulation of blood pressure]
GO:0045778 [positive regulation of ossification]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046878 [positive regulation of saliva secretion]
GO:0046887 [positive regulation of hormone secretion]
GO:0048265 [response to pain]
GO:0048266 [behavioral response to pain]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050671 [positive regulation of lymphocyte proliferation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051602 [response to electrical stimulus]
GO:0060083 [smooth muscle contraction involved in micturition]
GO:0070472 [regulation of uterine smooth muscle contraction]
GO:0070474 [positive regulation of uterine smooth muscle contraction]
GO:0071944 [cell periphery]
Show all
 407 aa
46.3 kDa 		No 7
TACR1-002
ENSP00000386448
ENST00000409848
P25103 [Direct mapping]
Substance-P receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004995 [tachykinin receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007217 [tachykinin receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0009582 [detection of abiotic stimulus]
GO:0016021 [integral component of membrane]
GO:0016496 [substance P receptor activity]
GO:0045987 [positive regulation of smooth muscle contraction]
Show all
 311 aa
35.7 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.