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Weak to moderate cytoplasmic and membranous staining was observed in a subset of tumor cells in several cancers, especially in squamous cell carcinomas. Remaining cancers were negative.
GENE INFORMATION
Gene name
TACR1 (HGNC Symbol)
Synonyms
NK1R, NKIR, SPR, TAC1R
Description
Tachykinin receptor 1 (HGNC Symbol)
Entrez gene summary
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]