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CCDC88A

GENERAL INFORMATION

Gene name

 CCDC88A

Gene description

 Coiled-coil domain containing 88A

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Abundant cytoplasmic expression in lymphatic organs.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA038101 , HPA038102
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CCDC88A (HGNC Symbol)

Synonyms

 APE, FLJ10392, GIV, GRDN, HkRP1, KIAA1212

Description

 Coiled-coil domain containing 88A (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Chromosome

 2

Cytoband

 p16.1

Chromosome location (bp)

 55287842 - 55419921

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115355 (version 83.38)

Entrez gene

 55704

UniProt

 Q3V6T2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q3V6T2

Antibodypedia

 CCDC88A antibodies

PROTEIN BROWSER
CCDC88A-001
CCDC88A-002
CCDC88A-003
CCDC88A-005
CCDC88A-006
CCDC88A-008
CCDC88A-009
CCDC88A-201
CCDC88A-202
CCDC88A-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCDC88A-001
ENSP00000263630
ENST00000263630
Q3V6T2 [Direct mapping]
Girdin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001932 [regulation of protein phosphorylation]
GO:0003779 [actin binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006260 [DNA replication]
GO:0006275 [regulation of DNA replication]
GO:0008017 [microtubule binding]
GO:0010975 [regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0031410 [cytoplasmic vesicle]
GO:0031929 [TOR signaling]
GO:0032148 [activation of protein kinase B activity]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0035091 [phosphatidylinositol binding]
GO:0042127 [regulation of cell proliferation]
GO:0042803 [protein homodimerization activity]
GO:0043422 [protein kinase B binding]
GO:0061024 [membrane organization]
Show all
 1843 aa
212.6 kDa 		No 0
CCDC88A-002
ENSP00000338728
ENST00000336838
Q3V6T2 [Direct mapping]
Girdin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001932 [regulation of protein phosphorylation]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006260 [DNA replication]
GO:0006275 [regulation of DNA replication]
GO:0008017 [microtubule binding]
GO:0010975 [regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0031410 [cytoplasmic vesicle]
GO:0031929 [TOR signaling]
GO:0032148 [activation of protein kinase B activity]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0035091 [phosphatidylinositol binding]
GO:0042127 [regulation of cell proliferation]
GO:0042803 [protein homodimerization activity]
GO:0043422 [protein kinase B binding]
GO:0061024 [membrane organization]
Show all
 1870 aa
216 kDa 		No 0
CCDC88A-003
ENSP00000413401
ENST00000444458
H0Y7K3 [Direct mapping]
Girdin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0016477 [cell migration]
GO:0032956 [regulation of actin cytoskeleton organization]
Show all
 374 aa
41 kDa 		No 0
CCDC88A-005
ENSP00000405080
ENST00000426576
H7C2C6 [Direct mapping]
Girdin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0016477 [cell migration]
GO:0032956 [regulation of actin cytoskeleton organization]
Show all
 1202 aa
136.6 kDa 		No 0
CCDC88A-006
ENSP00000390012
ENST00000412148
H0Y470 [Direct mapping]
Girdin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0016477 [cell migration]
GO:0032956 [regulation of actin cytoskeleton organization]
Show all
 888 aa
100.6 kDa 		No 0
CCDC88A-008
ENSP00000415267
ENST00000456975
H0Y7U8 [Direct mapping]
Girdin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0016477 [cell migration]
GO:0032956 [regulation of actin cytoskeleton organization]
Show all
 737 aa
83.5 kDa 		No 0
CCDC88A-009
ENSP00000399237
ENST00000430086
C9J225 [Direct mapping]
Girdin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0016477 [cell migration]
GO:0032956 [regulation of actin cytoskeleton organization]
Show all
 147 aa
17.1 kDa 		No 0
CCDC88A-201
ENSP00000404431
ENST00000413716
Q3V6T2 [Direct mapping]
Girdin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001932 [regulation of protein phosphorylation]
GO:0003779 [actin binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006260 [DNA replication]
GO:0006275 [regulation of DNA replication]
GO:0008017 [microtubule binding]
GO:0010975 [regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0031410 [cytoplasmic vesicle]
GO:0031929 [TOR signaling]
GO:0032148 [activation of protein kinase B activity]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0035091 [phosphatidylinositol binding]
GO:0042127 [regulation of cell proliferation]
GO:0042803 [protein homodimerization activity]
GO:0043422 [protein kinase B binding]
GO:0061024 [membrane organization]
Show all
 1796 aa
207.8 kDa 		No 0
CCDC88A-202
ENSP00000410608
ENST00000436346
Q3V6T2 [Direct mapping]
Girdin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001932 [regulation of protein phosphorylation]
GO:0003779 [actin binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006260 [DNA replication]
GO:0006275 [regulation of DNA replication]
GO:0008017 [microtubule binding]
GO:0010975 [regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0031410 [cytoplasmic vesicle]
GO:0031929 [TOR signaling]
GO:0032148 [activation of protein kinase B activity]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0035091 [phosphatidylinositol binding]
GO:0042127 [regulation of cell proliferation]
GO:0042803 [protein homodimerization activity]
GO:0043422 [protein kinase B binding]
GO:0061024 [membrane organization]
Show all
 1871 aa
216 kDa 		No 0
CCDC88A-203
ENSP00000480931
ENST00000621814
A0A087WXD9 [Direct mapping]
Girdin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0016477 [cell migration]
GO:0032956 [regulation of actin cytoskeleton organization]
Show all
 741 aa
87.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.