Expression of LANCL1 in cancer - Summary - The Human Protein Atlas

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LANCL1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LANCL1
Gene description	LanC lantibiotic synthetase component C-like 1 (bacterial)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA034994
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034994

GENE INFORMATION
Gene name	LANCL1 (HGNC Symbol)
Synonyms	GPR69A, p40
Description	LanC lantibiotic synthetase component C-like 1 (bacterial) (HGNC Symbol)
Entrez gene summary	This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
Chromosome	2
Cytoband	q34
Chromosome location (bp)	210431249 - 210477652
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115365 (version 83.38)
Entrez gene	10314
UniProt	O43813 (UniProt - Evidence at protein level)
neXtProt	NX_O43813
Antibodypedia	LANCL1 antibodies

PROTEIN BROWSER

LANCL1-001	LANCL1-003	LANCL1-004	LANCL1-005	LANCL1-007	LANCL1-008	LANCL1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LANCL1-001 ENSP00000393597 ENST00000450366	O43813 [Direct mapping] LanC-like protein 1 Q53TN2 [Target identity:100%; Query identity:100%] LanC lantibiotic synthetase component C-like 1 (Bacterial), isoform CRA_a; Putative uncharacterized protein LANCL1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0017124 [SH3 domain binding] GO:0043295 [glutathione binding] GO:0050750 [low-density lipoprotein particle receptor binding] GO:0070062 [extracellular exosome] Show all	399 aa 45.3 kDa	No	0
LANCL1-003 ENSP00000397646 ENST00000431941	O43813 [Direct mapping] LanC-like protein 1 Q53TN2 [Target identity:100%; Query identity:100%] LanC lantibiotic synthetase component C-like 1 (Bacterial), isoform CRA_a; Putative uncharacterized protein LANCL1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0017124 [SH3 domain binding] GO:0043295 [glutathione binding] GO:0050750 [low-density lipoprotein particle receptor binding] GO:0070062 [extracellular exosome] Show all	399 aa 45.3 kDa	No	0
LANCL1-004 ENSP00000233714 ENST00000233714	O43813 [Direct mapping] LanC-like protein 1 Q53TN2 [Target identity:100%; Query identity:100%] LanC lantibiotic synthetase component C-like 1 (Bacterial), isoform CRA_a; Putative uncharacterized protein LANCL1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0017124 [SH3 domain binding] GO:0043295 [glutathione binding] GO:0050750 [low-density lipoprotein particle receptor binding] GO:0070062 [extracellular exosome] Show all	399 aa 45.3 kDa	No	0
LANCL1-005 ENSP00000388713 ENST00000443314	O43813 [Direct mapping] LanC-like protein 1 Q53TN2 [Target identity:100%; Query identity:100%] LanC lantibiotic synthetase component C-like 1 (Bacterial), isoform CRA_a; Putative uncharacterized protein LANCL1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0017124 [SH3 domain binding] GO:0043295 [glutathione binding] GO:0050750 [low-density lipoprotein particle receptor binding] GO:0070062 [extracellular exosome] Show all	399 aa 45.3 kDa	No	0
LANCL1-007 ENSP00000393323 ENST00000441020	O43813 [Direct mapping] LanC-like protein 1 Q53TN2 [Target identity:100%; Query identity:100%] LanC lantibiotic synthetase component C-like 1 (Bacterial), isoform CRA_a; Putative uncharacterized protein LANCL1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0017124 [SH3 domain binding] GO:0043295 [glutathione binding] GO:0050750 [low-density lipoprotein particle receptor binding] GO:0070062 [extracellular exosome] Show all	399 aa 45.3 kDa	No	0
LANCL1-008 ENSP00000396518 ENST00000448951	E9PHS0 [Direct mapping] LanC-like protein 1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		196 aa 22 kDa	No	0
LANCL1-010 ENSP00000405364 ENST00000412863	H7C2E3 [Direct mapping] LanC-like protein 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	148 aa 17 kDa	No	0

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