Tissue expression of LANCL1 - Summary - The Human Protein Atlas

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LANCL1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	LANCL1
Gene description	LanC lantibiotic synthetase component C-like 1 (bacterial)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA034994
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	LANCL1 (HGNC Symbol)
Synonyms	GPR69A, p40
Description	LanC lantibiotic synthetase component C-like 1 (bacterial) (HGNC Symbol)
Entrez gene summary	This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
Chromosome	2
Cytoband	q34
Chromosome location (bp)	210431249 - 210477652
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115365 (version 83.38)
Entrez gene	10314
UniProt	O43813 (UniProt - Evidence at protein level)
neXtProt	NX_O43813
Antibodypedia	LANCL1 antibodies

PROTEIN BROWSER

LANCL1-001	LANCL1-003	LANCL1-004	LANCL1-005	LANCL1-007	LANCL1-008	LANCL1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LANCL1-001 ENSP00000393597 ENST00000450366	O43813 [Direct mapping] LanC-like protein 1 Q53TN2 [Target identity:100%; Query identity:100%] LanC lantibiotic synthetase component C-like 1 (Bacterial), isoform CRA_a; Putative uncharacterized protein LANCL1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0017124 [SH3 domain binding] GO:0043295 [glutathione binding] GO:0050750 [low-density lipoprotein particle receptor binding] GO:0070062 [extracellular exosome] Show all	399 aa 45.3 kDa	No	0
LANCL1-003 ENSP00000397646 ENST00000431941	O43813 [Direct mapping] LanC-like protein 1 Q53TN2 [Target identity:100%; Query identity:100%] LanC lantibiotic synthetase component C-like 1 (Bacterial), isoform CRA_a; Putative uncharacterized protein LANCL1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0017124 [SH3 domain binding] GO:0043295 [glutathione binding] GO:0050750 [low-density lipoprotein particle receptor binding] GO:0070062 [extracellular exosome] Show all	399 aa 45.3 kDa	No	0
LANCL1-004 ENSP00000233714 ENST00000233714	O43813 [Direct mapping] LanC-like protein 1 Q53TN2 [Target identity:100%; Query identity:100%] LanC lantibiotic synthetase component C-like 1 (Bacterial), isoform CRA_a; Putative uncharacterized protein LANCL1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0017124 [SH3 domain binding] GO:0043295 [glutathione binding] GO:0050750 [low-density lipoprotein particle receptor binding] GO:0070062 [extracellular exosome] Show all	399 aa 45.3 kDa	No	0
LANCL1-005 ENSP00000388713 ENST00000443314	O43813 [Direct mapping] LanC-like protein 1 Q53TN2 [Target identity:100%; Query identity:100%] LanC lantibiotic synthetase component C-like 1 (Bacterial), isoform CRA_a; Putative uncharacterized protein LANCL1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0017124 [SH3 domain binding] GO:0043295 [glutathione binding] GO:0050750 [low-density lipoprotein particle receptor binding] GO:0070062 [extracellular exosome] Show all	399 aa 45.3 kDa	No	0
LANCL1-007 ENSP00000393323 ENST00000441020	O43813 [Direct mapping] LanC-like protein 1 Q53TN2 [Target identity:100%; Query identity:100%] LanC lantibiotic synthetase component C-like 1 (Bacterial), isoform CRA_a; Putative uncharacterized protein LANCL1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0017124 [SH3 domain binding] GO:0043295 [glutathione binding] GO:0050750 [low-density lipoprotein particle receptor binding] GO:0070062 [extracellular exosome] Show all	399 aa 45.3 kDa	No	0
LANCL1-008 ENSP00000396518 ENST00000448951	E9PHS0 [Direct mapping] LanC-like protein 1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		196 aa 22 kDa	No	0
LANCL1-010 ENSP00000405364 ENST00000412863	H7C2E3 [Direct mapping] LanC-like protein 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	148 aa 17 kDa	No	0

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The Human Protein Atlas

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