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STAT1

GENERAL INFORMATION

Gene name

 STAT1

Gene description

 Signal transducer and activator of transcription 1, 91kDa

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in selected tissues, most abundant in lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA000931 , HPA000982 , CAB004049
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), ovarian cancer (favourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Ovarian cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA000931
HPA000982
CAB004049

GENE INFORMATION

Gene name

 STAT1 (HGNC Symbol)

Synonyms

 ISGF-3, STAT91

Description

 Signal transducer and activator of transcription 1, 91kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q32.2

Chromosome location (bp)

 190964358 - 191020960

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115415 (version 83.38)

Entrez gene

 6772

UniProt

 P42224 (UniProt - Evidence at protein level)

neXtProt

 NX_P42224

Antibodypedia

 STAT1 antibodies

PROTEIN BROWSER
STAT1-001
STAT1-002
STAT1-003
STAT1-004
STAT1-007
STAT1-008
STAT1-011
STAT1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STAT1-001
ENSP00000354394
ENST00000361099
P42224 [Direct mapping]
Signal transducer and activator of transcription 1-alpha/beta
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003340 [negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007259 [JAK-STAT cascade]
GO:0008015 [blood circulation]
GO:0009617 [response to bacterium]
GO:0016032 [viral process]
GO:0016525 [negative regulation of angiogenesis]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034097 [response to cytokine]
GO:0034240 [negative regulation of macrophage fusion]
GO:0035456 [response to interferon-beta]
GO:0035458 [cellular response to interferon-beta]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043330 [response to exogenous dsRNA]
GO:0043434 [response to peptide hormone]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046725 [negative regulation by virus of viral protein levels in host cell]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0051591 [response to cAMP]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0061326 [renal tubule development]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0072136 [metanephric mesenchymal cell proliferation involved in metanephros development]
GO:0072162 [metanephric mesenchymal cell differentiation]
GO:0072308 [negative regulation of metanephric nephron tubule epithelial cell differentiation]
Show all
 750 aa
87.3 kDa 		No 0
STAT1-002
ENSP00000376137
ENST00000392323
J3KPM9 [Direct mapping]
Signal transducer and activator of transcription
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 714 aa
83.4 kDa 		No 0
STAT1-003
ENSP00000376136
ENST00000392322
P42224 [Direct mapping]
Signal transducer and activator of transcription 1-alpha/beta
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003340 [negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007259 [JAK-STAT cascade]
GO:0008015 [blood circulation]
GO:0016032 [viral process]
GO:0016525 [negative regulation of angiogenesis]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034097 [response to cytokine]
GO:0035456 [response to interferon-beta]
GO:0035458 [cellular response to interferon-beta]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043434 [response to peptide hormone]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046725 [negative regulation by virus of viral protein levels in host cell]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0051591 [response to cAMP]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0061326 [renal tubule development]
GO:0072136 [metanephric mesenchymal cell proliferation involved in metanephros development]
GO:0072162 [metanephric mesenchymal cell differentiation]
GO:0072308 [negative regulation of metanephric nephron tubule epithelial cell differentiation]
Show all
 712 aa
83 kDa 		No 0
STAT1-004
ENSP00000402548
ENST00000424722
E7EPD2 [Direct mapping]
Signal transducer and activator of transcription 1-alpha/beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 180 aa
21.8 kDa 		No 0
STAT1-007
ENSP00000416019
ENST00000432058
E9PH66 [Direct mapping]
Signal transducer and activator of transcription 1-alpha/beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 70 aa
8.6 kDa 		No 0
STAT1-008
ENSP00000411398
ENST00000454414
E7ENM1 [Direct mapping]
Signal transducer and activator of transcription 1-alpha/beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 150 aa
18.1 kDa 		No 0
STAT1-011
ENSP00000386244
ENST00000409465
P42224 [Direct mapping]
Signal transducer and activator of transcription 1-alpha/beta
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003340 [negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007259 [JAK-STAT cascade]
GO:0008015 [blood circulation]
GO:0016032 [viral process]
GO:0016525 [negative regulation of angiogenesis]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034097 [response to cytokine]
GO:0035456 [response to interferon-beta]
GO:0035458 [cellular response to interferon-beta]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043434 [response to peptide hormone]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046725 [negative regulation by virus of viral protein levels in host cell]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0051591 [response to cAMP]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0061326 [renal tubule development]
GO:0072136 [metanephric mesenchymal cell proliferation involved in metanephros development]
GO:0072162 [metanephric mesenchymal cell differentiation]
GO:0072308 [negative regulation of metanephric nephron tubule epithelial cell differentiation]
Show all
 750 aa
87.3 kDa 		No 0
STAT1-201
ENSP00000438703
ENST00000540176
D2KFR9 [Direct mapping]
Signal transducer and activator of transcription 1-alpha/beta; Truncated signal transducer and activator of transcription 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 193 aa
23.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.