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DNAH6

GENERAL INFORMATION

Gene name

 DNAH6

Gene description

 Dynein, axonemal, heavy chain 6

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Not detected
HPA (normal tissue):Tissue enhanced (fallopian tube, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in cilia in fallopian tube and respiratory epithelia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA036391
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA036391

GENE INFORMATION

Gene name

 DNAH6 (HGNC Symbol)

Synonyms

 Dnahc6, DNHL1, FLJ37357, HL-2

Description

 Dynein, axonemal, heavy chain 6 (HGNC Symbol)

Entrez gene summary

 Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH6 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).[supplied by OMIM, Mar 2008]

Chromosome

 2

Cytoband

 p11.2

Chromosome location (bp)

 84516455 - 84819589

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115423 (version 83.38)

Entrez gene

 1768

UniProt

 Q9C0G6 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9C0G6

Antibodypedia

 DNAH6 antibodies

PROTEIN BROWSER
DNAH6-001
DNAH6-007
DNAH6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNAH6-001
ENSP00000237449
ENST00000237449
Q9C0G6 [Direct mapping]
Dynein heavy chain 6, axonemal
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
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GO:0001539 [cilium or flagellum-dependent cell motility]
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005858 [axonemal dynein complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
GO:0030286 [dynein complex]
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 4158 aa
476 kDa 		No 0
DNAH6-007
ENSP00000473441
ENST00000602588
A0A0C4DGR9 [Direct mapping]
Dynein heavy chain 6, axonemal
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0001539 [cilium or flagellum-dependent cell motility]
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005858 [axonemal dynein complex]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
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 551 aa
63 kDa 		No 0
DNAH6-201
ENSP00000374045
ENST00000389394
Q9C0G6 [Direct mapping]
Dynein heavy chain 6, axonemal
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0001539 [cilium or flagellum-dependent cell motility]
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005858 [axonemal dynein complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
GO:0030286 [dynein complex]
Show all
 4158 aa
476 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.