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DNAH6

GENERAL INFORMATION

Gene name

 DNAH6

Gene description

 Dynein, axonemal, heavy chain 6

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (fallopian tube, testis)
GTEx:Tissue enhanced (testis)
FANTOM5:Tissue enhanced (caudate, pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in cilia in fallopian tube and respiratory epithelia.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA036391
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (fallopian tube, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, pituitary gland)

GENE INFORMATION

Gene name

 DNAH6 (HGNC Symbol)

Synonyms

 Dnahc6, DNHL1, FLJ37357, HL-2

Description

 Dynein, axonemal, heavy chain 6 (HGNC Symbol)

Entrez gene summary

 Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH6 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).[supplied by OMIM, Mar 2008]

Chromosome

 2

Cytoband

 p11.2

Chromosome location (bp)

 84516455 - 84819589

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115423 (version 83.38)

Entrez gene

 1768

UniProt

 Q9C0G6 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9C0G6

Antibodypedia

 DNAH6 antibodies

PROTEIN BROWSER
DNAH6-001
DNAH6-007
DNAH6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNAH6-001
ENSP00000237449
ENST00000237449
Q9C0G6 [Direct mapping]
Dynein heavy chain 6, axonemal
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Show all
GO:0001539 [cilium or flagellum-dependent cell motility]
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005858 [axonemal dynein complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
GO:0030286 [dynein complex]
Show all
 4158 aa
476 kDa 		No 0
DNAH6-007
ENSP00000473441
ENST00000602588
A0A0C4DGR9 [Direct mapping]
Dynein heavy chain 6, axonemal
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0001539 [cilium or flagellum-dependent cell motility]
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005858 [axonemal dynein complex]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 551 aa
63 kDa 		No 0
DNAH6-201
ENSP00000374045
ENST00000389394
Q9C0G6 [Direct mapping]
Dynein heavy chain 6, axonemal
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0001539 [cilium or flagellum-dependent cell motility]
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005858 [axonemal dynein complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
GO:0030286 [dynein complex]
Show all
 4158 aa
476 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.