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IGFBP2

GENERAL INFORMATION

Gene name

 IGFBP2

Gene description

 Insulin-like growth factor binding protein 2, 36kDa

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (HMC-1)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and melanoma (unfavourable).
Renal cancer p<0.001
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 IGFBP2 (HGNC Symbol)

Synonyms

 IBP2

Description

 Insulin-like growth factor binding protein 2, 36kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 216632828 - 216664436

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115457 (version 83.38)

Entrez gene

 3485

UniProt

 P18065 (UniProt - Evidence at protein level)

neXtProt

 NX_P18065

Antibodypedia

 IGFBP2 antibodies

PROTEIN BROWSER
IGFBP2-001
IGFBP2-003
IGFBP2-004
IGFBP2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IGFBP2-001
ENSP00000233809
ENST00000233809
P18065 [Direct mapping]
Insulin-like growth factor-binding protein 2
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005515 [protein binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007165 [signal transduction]
GO:0007565 [female pregnancy]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0009612 [response to mechanical stimulus]
GO:0010226 [response to lithium ion]
GO:0016324 [apical plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0031994 [insulin-like growth factor I binding]
GO:0031995 [insulin-like growth factor II binding]
GO:0032355 [response to estradiol]
GO:0032526 [response to retinoic acid]
GO:0032870 [cellular response to hormone stimulus]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042493 [response to drug]
GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway]
GO:0043627 [response to estrogen]
GO:0044267 [cellular protein metabolic process]
GO:0048545 [response to steroid hormone]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
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 325 aa
34.8 kDa 		Yes 0
IGFBP2-003
ENSP00000401698
ENST00000434997
C9JW52 [Direct mapping]
Insulin-like growth factor-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0031995 [insulin-like growth factor II binding]
GO:0032868 [response to insulin]
GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway]
Show all
 78 aa
8.7 kDa 		No 0
IGFBP2-004
ENSP00000389646
ENST00000456764
C9JMY1 [Direct mapping]
Insulin-like growth factor-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0031995 [insulin-like growth factor II binding]
GO:0032868 [response to insulin]
GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway]
Show all
 181 aa
20.3 kDa 		No 0
IGFBP2-005
ENSP00000400308
ENST00000436812
H7C1H0 [Direct mapping]
Insulin-like growth factor-binding protein 2
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   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0031995 [insulin-like growth factor II binding]
GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway]
Show all
 98 aa
10.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.