Tissue expression of IGFBP2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	IGFBP2
Gene description	Insulin-like growth factor binding protein 2, 36kDa
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	IGFBP2 (HGNC Symbol)
Synonyms	IBP2
Description	Insulin-like growth factor binding protein 2, 36kDa (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	216632828 - 216664436
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115457 (version 83.38)
Entrez gene	3485
UniProt	P18065 (UniProt - Evidence at protein level)
neXtProt	NX_P18065
Antibodypedia	IGFBP2 antibodies

PROTEIN BROWSER

IGFBP2-001	IGFBP2-003	IGFBP2-004	IGFBP2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IGFBP2-001 ENSP00000233809 ENST00000233809	P18065 [Direct mapping] Insulin-like growth factor-binding protein 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005515 [protein binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0007565 [female pregnancy] GO:0007568 [aging] GO:0007584 [response to nutrient] GO:0009612 [response to mechanical stimulus] GO:0010226 [response to lithium ion] GO:0016324 [apical plasma membrane] GO:0031410 [cytoplasmic vesicle] GO:0031994 [insulin-like growth factor I binding] GO:0031995 [insulin-like growth factor II binding] GO:0032355 [response to estradiol] GO:0032526 [response to retinoic acid] GO:0032870 [cellular response to hormone stimulus] GO:0042104 [positive regulation of activated T cell proliferation] GO:0042493 [response to drug] GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway] GO:0043627 [response to estrogen] GO:0044267 [cellular protein metabolic process] GO:0048545 [response to steroid hormone] GO:0051384 [response to glucocorticoid] GO:0070062 [extracellular exosome] Show all	325 aa 34.8 kDa	Yes	0
IGFBP2-003 ENSP00000401698 ENST00000434997	C9JW52 [Direct mapping] Insulin-like growth factor-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0031995 [insulin-like growth factor II binding] GO:0032868 [response to insulin] GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway] Show all	78 aa 8.7 kDa	No	0
IGFBP2-004 ENSP00000389646 ENST00000456764	C9JMY1 [Direct mapping] Insulin-like growth factor-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0031995 [insulin-like growth factor II binding] GO:0032868 [response to insulin] GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway] Show all	181 aa 20.3 kDa	No	0
IGFBP2-005 ENSP00000400308 ENST00000436812	H7C1H0 [Direct mapping] Insulin-like growth factor-binding protein 2 Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0031995 [insulin-like growth factor II binding] GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway] Show all	98 aa 10.4 kDa	No	0