Cell atlas - OTX1 - The Human Protein Atlas

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OTX1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear speckles

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	OTX1
Gene description	Orthodenticle homeobox 1
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nuclear speckles.
RNA cell category	Cell line enriched (THP-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (uncertain), Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. CAB012341
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (THP-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nuclear speckles.

Main location

Nuclear speckles (uncertain), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB012341	A-431	No staining
	CAB012341	U-2 OS	Nuclear speckles
	CAB012341	U-2 OS	Cytosol
	CAB012341	U-251 MG	Nuclear speckles
	CAB012341	U-251 MG	Cytosol

GENE INFORMATION
Gene name	OTX1
Synonyms
Description	Orthodenticle homeobox 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mouse is required for proper brain and sensory organ development and can cause epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Chromosome	2
Cytoband	p15
Chromosome location (bp)	63050057 - 63057836
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115507 (version 83.38)
Entrez gene	5013
UniProt	P32242 (UniProt - Evidence at protein level)
neXtProt	NX_P32242
Antibodypedia	OTX1 antibodies

PROTEIN BROWSER

OTX1-001	OTX1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OTX1-001 ENSP00000282549 ENST00000282549	P32242 [Direct mapping] Homeobox protein OTX1 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007275 [multicellular organismal development] GO:0009952 [anterior/posterior pattern specification] GO:0022037 [metencephalon development] GO:0030900 [forebrain development] GO:0030901 [midbrain development] GO:0042472 [inner ear morphogenesis] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048852 [diencephalon morphogenesis] Show all	354 aa 37.3 kDa	No	0
OTX1-002 ENSP00000355631 ENST00000366671	P32242 [Direct mapping] Homeobox protein OTX1 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007275 [multicellular organismal development] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	354 aa 37.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.