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OTX1

GENERAL INFORMATION

Gene name

 OTX1

Gene description

 Orthodenticle homeobox 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, skin)
GTEx:Group enriched (salivary gland, skin)
FANTOM5:Group enriched (hippocampus, retina, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Expression in skin and in processes in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA052122
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (salivary gland, skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (hippocampus, retina, tonsil)

GENE INFORMATION

Gene name

 OTX1

Synonyms

Description

 Orthodenticle homeobox 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mouse is required for proper brain and sensory organ development and can cause epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Chromosome

 2

Cytoband

 p15

Chromosome location (bp)

 63050057 - 63057836

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115507 (version 83.38)

Entrez gene

 5013

UniProt

 P32242 (UniProt - Evidence at protein level)

neXtProt

 NX_P32242

Antibodypedia

 OTX1 antibodies

PROTEIN BROWSER
OTX1-001
OTX1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OTX1-001
ENSP00000282549
ENST00000282549
P32242 [Direct mapping]
Homeobox protein OTX1
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0009952 [anterior/posterior pattern specification]
GO:0022037 [metencephalon development]
GO:0030900 [forebrain development]
GO:0030901 [midbrain development]
GO:0042472 [inner ear morphogenesis]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048852 [diencephalon morphogenesis]
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 354 aa
37.3 kDa 		No 0
OTX1-002
ENSP00000355631
ENST00000366671
P32242 [Direct mapping]
Homeobox protein OTX1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 354 aa
37.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.