Cell atlas - ABCB6 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ABCB6
Gene description	ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus. In addition localized to the plasma membrane, cytosol, mitochondria & nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (validated)
Additional location	In addition localized to the Nucleoplasm (supported), Plasma membrane (supported), Mitochondria (supported), Cytosol (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA046723 , HPA058011
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus. In addition localized to the plasma membrane, cytosol, mitochondria & nucleoplasm.

Main location

Golgi apparatus (validated)

Additional location

Nucleoplasm (supported), Plasma membrane (supported), Mitochondria (supported), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA046723	Hep G2	Golgi apparatus
HPA046723	Hep G2	Plasma membrane
HPA046723	U-2 OS	Plasma membrane
HPA046723	U-251 MG	Golgi apparatus	Intensity
HPA058011	Hep G2	Golgi apparatus
HPA058011	Hep G2	Cytosol
HPA058011	U-2 OS	Mitochondria
HPA058011	U-251 MG	Nucleoplasm
HPA058011	U-251 MG	Golgi apparatus

GENE INFORMATION
Gene name	ABCB6 (HGNC Symbol)
Synonyms	EST45597, MTABC3, umat
Description	ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) (HGNC Symbol)
Entrez gene summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	219209768 - 219218990
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115657 (version 83.38)
Entrez gene	10058
UniProt	Q9NP58 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NP58
Antibodypedia	ABCB6 antibodies

PROTEIN BROWSER

ABCB6-001	ABCB6-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCB6-001 ENSP00000265316 ENST00000265316	Q9NP58 [Direct mapping] ATP-binding cassette sub-family B member 6, mitochondrial Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005741 [mitochondrial outer membrane] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006779 [porphyrin-containing compound biosynthetic process] GO:0006810 [transport] GO:0006879 [cellular iron ion homeostasis] GO:0007420 [brain development] GO:0015232 [heme transporter activity] GO:0015439 [heme-transporting ATPase activity] GO:0015562 [efflux transmembrane transporter activity] GO:0015886 [heme transport] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0020037 [heme binding] GO:0031307 [integral component of mitochondrial outer membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0043190 [ATP-binding cassette (ABC) transporter complex] GO:0043588 [skin development] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	842 aa 93.9 kDa	No	>9
ABCB6-005 ENSP00000295750 ENST00000295750	H7BXK9 [Direct mapping] ATP-binding cassette sub-family B member 6, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	690 aa 77.4 kDa	No	9