The majority of cancer tissues showed weak to moderate cytoplasmic staining. Membranous positivity was observed in colorectal and endometrial cancers. A few cases of melanoma, thyroid, lung, prostate, ovarian, urothelial, renal and liver cancers were strongly positive. Most cases of lymphomas were negative.
ABCB6 (HGNC Symbol)
EST45597, MTABC3, umat
ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) (HGNC Symbol)
Entrez gene summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function. [provided by RefSeq, Jul 2008]