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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ABCB6
  • TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ABCB6

Gene description

ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)

Protein class

Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA046723
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA046723

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

The majority of cancer tissues showed weak to moderate cytoplasmic staining. Membranous positivity was observed in colorectal and endometrial cancers. A few cases of melanoma, thyroid, lung, prostate, ovarian, urothelial, renal and liver cancers were strongly positive. Most cases of lymphomas were negative.

GENE INFORMATION

Gene name

ABCB6 (HGNC Symbol)

Synonyms

EST45597, MTABC3, umat

Description

ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) (HGNC Symbol)

Entrez gene summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q35

Chromosome location (bp)

219209768 - 219218990

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115657 (version 83.38)

Entrez gene

10058

UniProt

Q9NP58 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NP58

Antibodypedia

ABCB6 antibodies

PROTEIN BROWSER

ABCB6-001
ABCB6-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCB6-001
ENSP00000265316
ENST00000265316
Q9NP58 [Direct mapping]
ATP-binding cassette sub-family B member 6, mitochondrial
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005740 [mitochondrial envelope]
GO:0005741 [mitochondrial outer membrane]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006779 [porphyrin-containing compound biosynthetic process]
GO:0006810 [transport]
GO:0006879 [cellular iron ion homeostasis]
GO:0007420 [brain development]
GO:0015232 [heme transporter activity]
GO:0015439 [heme-transporting ATPase activity]
GO:0015562 [efflux transmembrane transporter activity]
GO:0015886 [heme transport]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0020037 [heme binding]
GO:0031307 [integral component of mitochondrial outer membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0043190 [ATP-binding cassette (ABC) transporter complex]
GO:0043588 [skin development]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
Show all
842 aa
93.9 kDa
No >9
ABCB6-005
ENSP00000295750
ENST00000295750
H7BXK9 [Direct mapping]
ATP-binding cassette sub-family B member 6, mitochondrial
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
690 aa
77.4 kDa
No 9

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