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The majority of cancer tissues showed weak to moderate cytoplasmic staining. Membranous positivity was observed in colorectal and endometrial cancers. A few cases of melanoma, thyroid, lung, prostate, ovarian, urothelial, renal and liver cancers were strongly positive. Most cases of lymphomas were negative.
GENE INFORMATION
Gene name
ABCB6 (HGNC Symbol)
Synonyms
EST45597, MTABC3, umat
Description
ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) (HGNC Symbol)
Entrez gene summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function. [provided by RefSeq, Jul 2008]