Expression of STK16 in cancer - Summary - The Human Protein Atlas

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STK16

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	STK16
Gene description	Serine/threonine kinase 16
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA029450
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029450

GENE INFORMATION
Gene name	STK16 (HGNC Symbol)
Synonyms	MPSK, PKL12
Description	Serine/threonine kinase 16 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q35
Chromosome location (bp)	219245455 - 219250337
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115661 (version 83.38)
Entrez gene	8576
UniProt	O75716 (UniProt - Evidence at protein level)
neXtProt	NX_O75716
Antibodypedia	STK16 antibodies

PROTEIN BROWSER

STK16-001	STK16-003	STK16-004	STK16-007	STK16-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STK16-001 ENSP00000386928 ENST00000409638	O75716 [Direct mapping] Serine/threonine-protein kinase 16 A0A024R440 [Target identity:100%; Query identity:100%] Serine/threonine kinase 16, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005798 [Golgi-associated vesicle] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046777 [protein autophosphorylation] GO:0048471 [perinuclear region of cytoplasm] GO:0071560 [cellular response to transforming growth factor beta stimulus] Show all	305 aa 34.7 kDa	No	0
STK16-003 ENSP00000386309 ENST00000409516	B4DPS1 [Direct mapping] Serine/threonine-protein kinase 16; cDNA FLJ60771, highly similar to Serine/threonine-protein kinase 16 (EC 2.7.11.1) Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	187 aa 20.7 kDa	No	0
STK16-004 ENSP00000379964 ENST00000396738	O75716 [Direct mapping] Serine/threonine-protein kinase 16 A0A024R440 [Target identity:100%; Query identity:100%] Serine/threonine kinase 16, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0046777 [protein autophosphorylation] GO:0048471 [perinuclear region of cytoplasm] Show all	305 aa 34.7 kDa	No	0
STK16-007 ENSP00000387156 ENST00000409260	B8ZZN3 [Direct mapping] Serine/threonine-protein kinase 16 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	350 aa 39.5 kDa	No	0
STK16-012 ENSP00000386553 ENST00000409743	B8ZZI5 [Direct mapping] Serine/threonine-protein kinase 16 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] Show all	273 aa 30.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.