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RNA cell line category: Cell line enriched (Hep G2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
GENE INFORMATION
Gene name
PROC
Synonyms
Description
Protein C (inactivator of coagulation factors Va and VIIIa) (HGNC Symbol)
Entrez gene summary
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]
P04070 [Direct mapping] Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide
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Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005796 [Golgi lumen] GO:0006508 [proteolysis] GO:0007596 [blood coagulation] GO:0008233 [peptidase activity] GO:0017187 [peptidyl-glutamic acid carboxylation] GO:0030195 [negative regulation of blood coagulation] GO:0043066 [negative regulation of apoptotic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0050728 [negative regulation of inflammatory response] GO:0050819 [negative regulation of coagulation] GO:0050900 [leukocyte migration] GO:1903142 [positive regulation of establishment of endothelial barrier]
