Expression of PROC in cancer - Summary - The Human Protein Atlas

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PROC

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PROC
Gene description	Protein C (inactivator of coagulation factors Va and VIIIa)
Protein class	Cancer-related genes Candidate cardiovascular disease genes Disease related genes Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enriched (Hep G2)
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Positivity in plasma and cytoplasmic expression in fractions of cell types.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 3 antibodies. HPA005550 , CAB016721 , CAB016792
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA005550	CAB016721	CAB016792

GENE INFORMATION
Gene name	PROC
Synonyms
Description	Protein C (inactivator of coagulation factors Va and VIIIa) (HGNC Symbol)
Entrez gene summary	This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]
Chromosome	2
Cytoband	q14.3
Chromosome location (bp)	127418427 - 127429246
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115718 (version 83.38)
Entrez gene	5624
UniProt	P04070 (UniProt - Evidence at protein level)
neXtProt	NX_P04070
Antibodypedia	PROC antibodies

PROTEIN BROWSER

PROC-001	PROC-002	PROC-003	PROC-006	PROC-010	PROC-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PROC-001 ENSP00000234071 ENST00000234071	P04070 [Direct mapping] Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005796 [Golgi lumen] GO:0006508 [proteolysis] GO:0007596 [blood coagulation] GO:0008233 [peptidase activity] GO:0017187 [peptidyl-glutamic acid carboxylation] GO:0030195 [negative regulation of blood coagulation] GO:0043066 [negative regulation of apoptotic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0050728 [negative regulation of inflammatory response] GO:0050819 [negative regulation of coagulation] GO:0050900 [leukocyte migration] GO:1903142 [positive regulation of establishment of endothelial barrier] Show all	461 aa 52.1 kDa	Yes	0
PROC-002 ENSP00000386679 ENST00000409048	E7END6 [Direct mapping] Vitamin K-dependent protein C Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0007596 [blood coagulation] Show all	495 aa 55.4 kDa	Yes	0
PROC-003 ENSP00000412697 ENST00000429925	E7EVH6 [Direct mapping] Osteocalcin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] Show all	126 aa 14.1 kDa	Yes	0
PROC-006 ENSP00000406295 ENST00000427769	E7EU72 [Direct mapping] Osteocalcin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] Show all	116 aa 13 kDa	Yes	0
PROC-010 ENSP00000411241 ENST00000442644	E7ENR9 [Direct mapping] Vitamin K-dependent protein C Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] Show all	175 aa 19.9 kDa	Yes	0
PROC-012 ENSP00000384225 ENST00000402125	H7BYX9 [Direct mapping] Vitamin K-dependent protein C Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	236 aa 26.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
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