Cell atlas - ODC1 - The Human Protein Atlas

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ODC1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	ODC1
Gene description	Ornithine decarboxylase 1
Protein class	Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. CAB035996
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cytosol.

Main location

Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB035996	A-431	Plasma membrane
	CAB035996	A-431	Cytosol
	CAB035996	U-2 OS	Plasma membrane
	CAB035996	U-2 OS	Cytosol
	CAB035996	U-251 MG	Plasma membrane
	CAB035996	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ODC1 (HGNC Symbol)
Synonyms	ODC
Description	Ornithine decarboxylase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]
Chromosome	2
Cytoband	p25.1
Chromosome location (bp)	10439968 - 10448504
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115758 (version 83.38)
Entrez gene	4953
UniProt	P11926 (UniProt - Evidence at protein level)
neXtProt	NX_P11926
Antibodypedia	ODC1 antibodies

PROTEIN BROWSER

ODC1-001	ODC1-002	ODC1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ODC1-001 ENSP00000234111 ENST00000234111	P11926 [Direct mapping] Ornithine decarboxylase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001822 [kidney development] GO:0003824 [catalytic activity] GO:0004586 [ornithine decarboxylase activity] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006595 [polyamine metabolic process] GO:0008284 [positive regulation of cell proliferation] GO:0009446 [putrescine biosynthetic process] GO:0009615 [response to virus] GO:0033387 [putrescine biosynthetic process from ornithine] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042176 [regulation of protein catabolic process] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0048471 [perinuclear region of cytoplasm] Show all	461 aa 51.1 kDa	No	0
ODC1-002 ENSP00000385333 ENST00000405333	P11926 [Direct mapping] Ornithine decarboxylase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004586 [ornithine decarboxylase activity] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006595 [polyamine metabolic process] GO:0009615 [response to virus] GO:0033387 [putrescine biosynthetic process from ornithine] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042176 [regulation of protein catabolic process] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] Show all	461 aa 51.1 kDa	No	0
ODC1-003 ENSP00000390691 ENST00000443218	C9JG30 [Direct mapping] Ornithine decarboxylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0033387 [putrescine biosynthetic process from ornithine] Show all	68 aa 7.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.