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ODC1

GENERAL INFORMATION

Gene name

 ODC1

Gene description

 Ornithine decarboxylase 1

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA001536 , CAB035996
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001536
CAB035996

GENE INFORMATION

Gene name

 ODC1 (HGNC Symbol)

Synonyms

 ODC

Description

 Ornithine decarboxylase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]

Chromosome

 2

Cytoband

 p25.1

Chromosome location (bp)

 10439968 - 10448504

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115758 (version 83.38)

Entrez gene

 4953

UniProt

 P11926 (UniProt - Evidence at protein level)

neXtProt

 NX_P11926

Antibodypedia

 ODC1 antibodies

PROTEIN BROWSER
ODC1-001
ODC1-002
ODC1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ODC1-001
ENSP00000234111
ENST00000234111
P11926 [Direct mapping]
Ornithine decarboxylase
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Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001822 [kidney development]
GO:0003824 [catalytic activity]
GO:0004586 [ornithine decarboxylase activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0009446 [putrescine biosynthetic process]
GO:0009615 [response to virus]
GO:0033387 [putrescine biosynthetic process from ornithine]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042176 [regulation of protein catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
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 461 aa
51.1 kDa 		No 0
ODC1-002
ENSP00000385333
ENST00000405333
P11926 [Direct mapping]
Ornithine decarboxylase
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004586 [ornithine decarboxylase activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0009615 [response to virus]
GO:0033387 [putrescine biosynthetic process from ornithine]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042176 [regulation of protein catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
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 461 aa
51.1 kDa 		No 0
ODC1-003
ENSP00000390691
ENST00000443218
C9JG30 [Direct mapping]
Ornithine decarboxylase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0033387 [putrescine biosynthetic process from ornithine]
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 68 aa
7.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.