Cell atlas - LCT - The Human Protein Atlas

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LCT

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	LCT
Gene description	Lactase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (RPMI-8226, MOLT-4)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RPMI-8226, MOLT-4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	LCT
Synonyms
Description	Lactase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the family 1 of glycosyl hydrolases. The protein is integral to plasma membrane and has both phlorizin hydrolase activity and lactase activity. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q21.3
Chromosome location (bp)	135787840 - 135837180
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115850 (version 83.38)
Entrez gene	3938
UniProt	P09848 (UniProt - Evidence at protein level)
neXtProt	NX_P09848
Antibodypedia	LCT antibodies

PROTEIN BROWSER

LCT-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LCT-001 ENSP00000264162 ENST00000264162	P09848 [Direct mapping] Lactase-phlorizin hydrolase Lactase Phlorizin hydrolase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0000016 [lactase activity] GO:0001666 [response to hypoxia] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005903 [brush border] GO:0005975 [carbohydrate metabolic process] GO:0007584 [response to nutrient] GO:0009725 [response to hormone] GO:0009744 [response to sucrose] GO:0010033 [response to organic substance] GO:0010040 [response to iron(II) ion] GO:0010045 [response to nickel cation] GO:0010288 [response to lead ion] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0016740 [transferase activity] GO:0017042 [glycosylceramidase activity] GO:0042493 [response to drug] GO:0042594 [response to starvation] GO:0043627 [response to estrogen] GO:0044245 [polysaccharide digestion] GO:0044281 [small molecule metabolic process] GO:0045471 [response to ethanol] Show all	1927 aa 218.6 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.