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LCT

GENERAL INFORMATION

Gene name

 LCT

Gene description

 Lactase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enhanced (MOLT-4, RPMI-8226)
HPA (normal tissue):Group enriched (duodenum, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in glandular cells, most abundant in gastrointestinal tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA007408
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007408

GENE INFORMATION

Gene name

 LCT

Synonyms

Description

 Lactase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the family 1 of glycosyl hydrolases. The protein is integral to plasma membrane and has both phlorizin hydrolase activity and lactase activity. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q21.3

Chromosome location (bp)

 135787840 - 135837180

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115850 (version 83.38)

Entrez gene

 3938

UniProt

 P09848 (UniProt - Evidence at protein level)

neXtProt

 NX_P09848

Antibodypedia

 LCT antibodies

PROTEIN BROWSER
LCT-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LCT-001
ENSP00000264162
ENST00000264162
P09848 [Direct mapping]
Lactase-phlorizin hydrolase Lactase Phlorizin hydrolase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
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GO:0000016 [lactase activity]
GO:0001666 [response to hypoxia]
GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0005975 [carbohydrate metabolic process]
GO:0007584 [response to nutrient]
GO:0009725 [response to hormone]
GO:0009744 [response to sucrose]
GO:0010033 [response to organic substance]
GO:0010040 [response to iron(II) ion]
GO:0010045 [response to nickel cation]
GO:0010288 [response to lead ion]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0016740 [transferase activity]
GO:0017042 [glycosylceramidase activity]
GO:0042493 [response to drug]
GO:0042594 [response to starvation]
GO:0043627 [response to estrogen]
GO:0044245 [polysaccharide digestion]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
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 1927 aa
218.6 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.