Fields »
ABOUT
HELP
BLOG
DARS

GENERAL INFORMATION

Gene name

 DARS

Gene description

 Aspartyl-tRNA synthetase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA020451 , HPA029804 , HPA029805
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable), pancreatic cancer (unfavourable) and melanoma (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Pancreatic cancer p<0.001
Melanoma p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA020451
HPA029804
HPA029805

GENE INFORMATION

Gene name

 DARS

Synonyms

Description

 Aspartyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a multienzyme complex that functions in mediating the attachment of amino acids to their cognate tRNAs. The encoded protein ligates L-aspartate to tRNA(Asp). Mutations in this gene have been found in patients showing hypomyelination with brainstem and spinal cord involvement and leg spasticity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Chromosome

 2

Cytoband

 q21.3

Chromosome location (bp)

 135906677 - 135986100

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115866 (version 83.38)

Entrez gene

 1615

UniProt

 P14868 (UniProt - Evidence at protein level)

neXtProt

 NX_P14868

Antibodypedia

 DARS antibodies

PROTEIN BROWSER
DARS-001
DARS-002
DARS-003
DARS-004
DARS-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DARS-001
ENSP00000264161
ENST00000264161
P14868 [Direct mapping]
Aspartate--tRNA ligase, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0004046 [aminoacylase activity]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004815 [aspartate-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006422 [aspartyl-tRNA aminoacylation]
GO:0006461 [protein complex assembly]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
Show all
 501 aa
57.1 kDa 		No 0
DARS-002
ENSP00000397616
ENST00000456565
C9J7S3 [Direct mapping]
Aspartate--tRNA ligase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0006418 [tRNA aminoacylation for protein translation]
Show all
 176 aa
20 kDa 		No 0
DARS-003
ENSP00000388801
ENST00000449218
C9JQM9 [Direct mapping]
Aspartate--tRNA ligase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0006418 [tRNA aminoacylation for protein translation]
Show all
 135 aa
15.3 kDa 		No 0
DARS-004
ENSP00000389867
ENST00000441323
C9JLC1 [Direct mapping]
Aspartate--tRNA ligase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0006418 [tRNA aminoacylation for protein translation]
Show all
 182 aa
20.6 kDa 		No 0
DARS-009
ENSP00000387508
ENST00000422708
H7BZ35 [Direct mapping]
Aspartate--tRNA ligase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0006418 [tRNA aminoacylation for protein translation]
Show all
 188 aa
21.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.