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AAK1

GENERAL INFORMATION

Gene name

 AAK1

Gene description

 AP2 associated kinase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (parathyroid gland)
GTEx:Tissue enhanced (cerebellum, cerebral cortex)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membrane expression at variable levels in several different cell types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA017931 , HPA020289
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Parathyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, cerebral cortex)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 AAK1 (HGNC Symbol)

Synonyms

 DKFZp686K16132, KIAA1048

Description

 AP2 associated kinase 1 (HGNC Symbol)

Entrez gene summary

 Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p13.3

Chromosome location (bp)

 69457997 - 69674349

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115977 (version 83.38)

Entrez gene

 22848

UniProt

 Q2M2I8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q2M2I8

Antibodypedia

 AAK1 antibodies

PROTEIN BROWSER
AAK1-001
AAK1-002
AAK1-011
AAK1-012
AAK1-013
AAK1-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AAK1-001
ENSP00000386456
ENST00000409085
Q2M2I8 [Direct mapping]
AP2-associated protein kinase 1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005112 [Notch binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005905 [coated pit]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0019897 [extrinsic component of plasma membrane]
GO:0030136 [clathrin-coated vesicle]
GO:0031252 [cell leading edge]
GO:0032880 [regulation of protein localization]
GO:0035612 [AP-2 adaptor complex binding]
GO:0043195 [terminal bouton]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0046777 [protein autophosphorylation]
GO:0050821 [protein stabilization]
GO:2000369 [regulation of clathrin-mediated endocytosis]
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 961 aa
103.9 kDa 		No 0
AAK1-002
ENSP00000385181
ENST00000406297
Q2M2I8 [Direct mapping]
AP2-associated protein kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005112 [Notch binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005905 [coated pit]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0019897 [extrinsic component of plasma membrane]
GO:0030136 [clathrin-coated vesicle]
GO:0031252 [cell leading edge]
GO:0032880 [regulation of protein localization]
GO:0035612 [AP-2 adaptor complex binding]
GO:0043195 [terminal bouton]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0046777 [protein autophosphorylation]
GO:0050821 [protein stabilization]
GO:2000369 [regulation of clathrin-mediated endocytosis]
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 863 aa
93.6 kDa 		No 0
AAK1-011
ENSP00000386342
ENST00000409068
E9PG46 [Direct mapping]
AP2-associated protein kinase 1
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 674 aa
73.8 kDa 		No 0
AAK1-012
ENSP00000485350
ENST00000606389
A0A096LP25 [Direct mapping]
AP2-associated protein kinase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 511 aa
54.4 kDa 		No 0
AAK1-013
ENSP00000485296
ENST00000623317
A0A096LNZ0 [Direct mapping]
AP2-associated protein kinase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 340 aa
36.4 kDa 		No 0
AAK1-014
ENSP00000485409
ENST00000624900
A0A096LP60 [Direct mapping]
AP2-associated protein kinase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 99 aa
10.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.