Cell atlas - MARK1 - The Human Protein Atlas

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MARK1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	MARK1
Gene description	MAP/microtubule affinity-regulating kinase 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (RT4)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RT4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	MARK1 (HGNC Symbol)
Synonyms	MARK, PAR-1C
Description	MAP/microtubule affinity-regulating kinase 1 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q41
Chromosome location (bp)	220528183 - 220664461
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116141 (version 83.38)
Entrez gene	4139
UniProt	Q9P0L2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P0L2
Antibodypedia	MARK1 antibodies

PROTEIN BROWSER

MARK1-001	MARK1-002	MARK1-201	MARK1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MARK1-001 ENSP00000355885 ENST00000366918	Q9P0L2 [Direct mapping] Serine/threonine-protein kinase MARK1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0001764 [neuron migration] GO:0001786 [phosphatidylserine binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007010 [cytoskeleton organization] GO:0015630 [microtubule cytoskeleton] GO:0016055 [Wnt signaling pathway] GO:0035556 [intracellular signal transduction] GO:0050321 [tau-protein kinase activity] GO:0070300 [phosphatidic acid binding] Show all	758 aa 84.9 kDa	No	0
MARK1-002 ENSP00000355884 ENST00000366917	Q9P0L2 [Direct mapping] Serine/threonine-protein kinase MARK1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0001764 [neuron migration] GO:0001786 [phosphatidylserine binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007010 [cytoskeleton organization] GO:0015630 [microtubule cytoskeleton] GO:0016055 [Wnt signaling pathway] GO:0035556 [intracellular signal transduction] GO:0050321 [tau-protein kinase activity] GO:0070300 [phosphatidic acid binding] Show all	795 aa 89 kDa	No	0
MARK1-201 ENSP00000386017 ENST00000402574	B4DIB3 [Direct mapping] MAP/microtubule affinity-regulating kinase 1, isoform CRA_a; Serine/threonine-protein kinase MARK1; cDNA FLJ58728, highly similar to Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	780 aa 87.5 kDa	No	0
MARK1-202 ENSP00000483424 ENST00000611084	A0A087X0I6 [Direct mapping] Serine/threonine-protein kinase MARK1 Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0000287 [magnesium ion binding] GO:0001764 [neuron migration] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006468 [protein phosphorylation] GO:0007010 [cytoskeleton organization] GO:0035556 [intracellular signal transduction] GO:0050321 [tau-protein kinase activity] Show all	796 aa 89.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.