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MARK1

GENERAL INFORMATION

Gene name

 MARK1

Gene description

 MAP/microtubule affinity-regulating kinase 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (RT4)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA007421 , HPA008061
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and melanoma (unfavourable).
Pancreatic cancer p<0.001
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA007421
HPA008061

GENE INFORMATION

Gene name

 MARK1 (HGNC Symbol)

Synonyms

 MARK, PAR-1C

Description

 MAP/microtubule affinity-regulating kinase 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 q41

Chromosome location (bp)

 220528183 - 220664461

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116141 (version 83.38)

Entrez gene

 4139

UniProt

 Q9P0L2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P0L2

Antibodypedia

 MARK1 antibodies

PROTEIN BROWSER
MARK1-001
MARK1-002
MARK1-201
MARK1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MARK1-001
ENSP00000355885
ENST00000366918
Q9P0L2 [Direct mapping]
Serine/threonine-protein kinase MARK1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001764 [neuron migration]
GO:0001786 [phosphatidylserine binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0015630 [microtubule cytoskeleton]
GO:0016055 [Wnt signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0050321 [tau-protein kinase activity]
GO:0070300 [phosphatidic acid binding]
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 758 aa
84.9 kDa 		No 0
MARK1-002
ENSP00000355884
ENST00000366917
Q9P0L2 [Direct mapping]
Serine/threonine-protein kinase MARK1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001764 [neuron migration]
GO:0001786 [phosphatidylserine binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0015630 [microtubule cytoskeleton]
GO:0016055 [Wnt signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0050321 [tau-protein kinase activity]
GO:0070300 [phosphatidic acid binding]
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 795 aa
89 kDa 		No 0
MARK1-201
ENSP00000386017
ENST00000402574
B4DIB3 [Direct mapping]
MAP/microtubule affinity-regulating kinase 1, isoform CRA_a; Serine/threonine-protein kinase MARK1; cDNA FLJ58728, highly similar to Serine/threonine-protein kinase MARK1 (EC 2.7.11.1)
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   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 780 aa
87.5 kDa 		No 0
MARK1-202
ENSP00000483424
ENST00000611084
A0A087X0I6 [Direct mapping]
Serine/threonine-protein kinase MARK1
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   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0000287 [magnesium ion binding]
GO:0001764 [neuron migration]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0035556 [intracellular signal transduction]
GO:0050321 [tau-protein kinase activity]
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 796 aa
89.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.