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TNR

GENERAL INFORMATION

Gene name

 TNR

Gene description

 Tenascin R

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (cerebral cortex, hippocampus, hypothalamus)
FANTOM5:Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct expression in neuropil.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA027134 , HPA027150 , HPA029859 , CAB022343
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, hippocampus, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland)

GENE INFORMATION

Gene name

 TNR

Synonyms

Description

 Tenascin R (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The encoded protein is restricted to the central nervous system. The protein may play a role in neurite outgrowth, neural cell adhesion and modulation of sodium channel function. It is a constituent of perineuronal nets. [provided by RefSeq, Aug 2013]

Chromosome

 1

Cytoband

 q25.1

Chromosome location (bp)

 175315194 - 175743770

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116147 (version 83.38)

Entrez gene

 7143

UniProt

 Q92752 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92752

Antibodypedia

 TNR antibodies

PROTEIN BROWSER
TNR-001
TNR-002
TNR-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNR-001
ENSP00000356646
ENST00000367674
Q92752 [Direct mapping]
Tenascin-R
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007155 [cell adhesion]
GO:0007158 [neuron cell-cell adhesion]
GO:0007411 [axon guidance]
GO:0008306 [associative learning]
GO:0009986 [cell surface]
GO:0010977 [negative regulation of neuron projection development]
GO:0022029 [telencephalon cell migration]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030198 [extracellular matrix organization]
GO:0030517 [negative regulation of axon extension]
GO:0035641 [locomotory exploration behavior]
GO:0045121 [membrane raft]
GO:0048692 [negative regulation of axon extension involved in regeneration]
GO:0050804 [modulation of synaptic transmission]
GO:0050805 [negative regulation of synaptic transmission]
GO:0050808 [synapse organization]
GO:0050885 [neuromuscular process controlling balance]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0051971 [positive regulation of transmission of nerve impulse]
GO:0060291 [long-term synaptic potentiation]
GO:0072534 [perineuronal net]
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 1358 aa
149.6 kDa 		Yes 0
TNR-002
ENSP00000403413
ENST00000422274
H0Y668 [Direct mapping]
Tenascin-R
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 181 aa
19.8 kDa 		No 0
TNR-201
ENSP00000263525
ENST00000263525
Q92752 [Direct mapping]
Tenascin-R
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007155 [cell adhesion]
GO:0007411 [axon guidance]
GO:0030198 [extracellular matrix organization]
Show all
 1358 aa
149.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.