Expression of PAPPA2 in cancer - Summary - The Human Protein Atlas

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PAPPA2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PAPPA2
Gene description	Pappalysin 2
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (U-87 MG)
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly selective cytoplasmic expression in a subset of trophoblastic cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA018412 , HPA018430
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018412	HPA018430

GENE INFORMATION
Gene name	PAPPA2 (HGNC Symbol)
Synonyms	PAPP-A2, PAPPE, PLAC3
Description	Pappalysin 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Chromosome	1
Cytoband	q25.2
Chromosome location (bp)	176463171 - 176845605
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116183 (version 83.38)
Entrez gene	60676
UniProt	Q9BXP8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BXP8
Antibodypedia	PAPPA2 antibodies

PROTEIN BROWSER

PAPPA2-001	PAPPA2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAPPA2-001 ENSP00000356634 ENST00000367662	Q9BXP8 [Direct mapping] Pappalysin-2 Show all	Enzymes Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005622 [intracellular] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0044267 [cellular protein metabolic process] GO:0060349 [bone morphogenesis] GO:0070062 [extracellular exosome] Show all	1791 aa 198.5 kDa	Yes	0
PAPPA2-002 ENSP00000356633 ENST00000367661	Q9BXP8 [Direct mapping] Pappalysin-2 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005576 [extracellular region] GO:0005622 [intracellular] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	827 aa 92.1 kDa	Yes	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.