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PAPPA2

GENERAL INFORMATION

Gene name

 PAPPA2

Gene description

 Pappalysin 2

Protein class

 Enzymes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (placenta)
GTEx:Tissue enhanced (kidney)
FANTOM5:Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

Protein expression

 Highly selective cytoplasmic expression in a subset of trophoblastic cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA018412 , HPA018430
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION

Gene name

 PAPPA2 (HGNC Symbol)

Synonyms

 PAPP-A2, PAPPE, PLAC3

Description

 Pappalysin 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Chromosome

 1

Cytoband

 q25.2

Chromosome location (bp)

 176463171 - 176845605

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116183 (version 83.38)

Entrez gene

 60676

UniProt

 Q9BXP8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BXP8

Antibodypedia

 PAPPA2 antibodies

PROTEIN BROWSER
PAPPA2-001
PAPPA2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAPPA2-001
ENSP00000356634
ENST00000367662
Q9BXP8 [Direct mapping]
Pappalysin-2
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Enzymes
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001558 [regulation of cell growth]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0044267 [cellular protein metabolic process]
GO:0060349 [bone morphogenesis]
GO:0070062 [extracellular exosome]
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 1791 aa
198.5 kDa 		Yes 0
PAPPA2-002
ENSP00000356633
ENST00000367661
Q9BXP8 [Direct mapping]
Pappalysin-2
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Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
Show all
 827 aa
92.1 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.