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MRPL37

GENERAL INFORMATION

Gene name

 MRPL37

Gene description

 Mitochondrial ribosomal protein L37

Protein class

 Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic staining with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA025767 , HPA025826 , HPA025951
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), colorectal cancer (favourable) and stomach cancer (favourable).
Liver cancer p<0.001
Colorectal cancer p<0.001
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA025767
HPA025826
HPA025951

GENE INFORMATION

Gene name

 MRPL37 (HGNC Symbol)

Synonyms

 MRP-L2, RPML2

Description

 Mitochondrial ribosomal protein L37 (HGNC Symbol)

Entrez gene summary

 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p32.3

Chromosome location (bp)

 54184041 - 54225464

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116221 (version 83.38)

Entrez gene

 51253

UniProt

 Q9BZE1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BZE1

Antibodypedia

 MRPL37 antibodies

PROTEIN BROWSER
MRPL37-001
MRPL37-003
MRPL37-005
MRPL37-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRPL37-001
ENSP00000354086
ENST00000360840
Q9BZE1 [Direct mapping]
39S ribosomal protein L37, mitochondrial
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Ribosomal proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
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 423 aa
48.1 kDa 		No 0
MRPL37-003
ENSP00000392216
ENST00000398219
H0Y4J2 [Direct mapping]
39S ribosomal protein L37, mitochondrial
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005739 [mitochondrion]
GO:0005840 [ribosome]
GO:0006412 [translation]
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 264 aa
29.5 kDa 		No 0
MRPL37-005
ENSP00000473980
ENST00000605337
S4R369 [Direct mapping]
39S ribosomal protein L37, mitochondrial
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005739 [mitochondrion]
GO:0005840 [ribosome]
GO:0006412 [translation]
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 483 aa
55 kDa 		No 0
MRPL37-201
ENSP00000338526
ENST00000336230
A6NHR2 [Direct mapping]
39S ribosomal protein L37, mitochondrial
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005739 [mitochondrion]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 292 aa
32.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.