Cell atlas - SRSF4 - The Human Protein Atlas

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SRSF4

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SRSF4
Gene description	Serine/arginine-rich splicing factor 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA050975
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA050975	A-431	Nuclear speckles
	HPA050975	HeLa	Nuclear speckles
	HPA050975	U-2 OS	Nuclear speckles

GENE INFORMATION
Gene name	SRSF4 (HGNC Symbol)
Synonyms	SFRS4, SRP75
Description	Serine/arginine-rich splicing factor 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the arginine/serine-rich splicing factor family. The encoded protein likely functions in mRNA processing. [provided by RefSeq, Feb 2009]
Chromosome	1
Cytoband	p35.3
Chromosome location (bp)	29147743 - 29181987
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116350 (version 83.38)
Entrez gene	6429
UniProt	Q08170 (UniProt - Evidence at protein level)
neXtProt	NX_Q08170
Antibodypedia	SRSF4 antibodies

PROTEIN BROWSER

SRSF4-001	SRSF4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SRSF4-001 ENSP00000362900 ENST00000373795	Q08170 [Direct mapping] Serine/arginine-rich splicing factor 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000375 [RNA splicing, via transesterification reactions] GO:0000398 [mRNA splicing, via spliceosome] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006369 [termination of RNA polymerase II transcription] GO:0006397 [mRNA processing] GO:0006406 [mRNA export from nucleus] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0016607 [nuclear speck] GO:0031124 [mRNA 3'-end processing] GO:0044822 [poly(A) RNA binding] GO:0048025 [negative regulation of mRNA splicing, via spliceosome] GO:1990825 [sequence-specific mRNA binding] Show all	494 aa 56.7 kDa	No	0
SRSF4-002 ENSP00000485813 ENST00000466448	A0A0D9SEM4 [Direct mapping] Serine/arginine-rich-splicing factor 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	378 aa 43.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.