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SRSF4

GENERAL INFORMATION

Gene name

 SRSF4

Gene description

 Serine/arginine-rich splicing factor 4

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA050975
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PROGNOSTIC SUMMARY
Prognostic marker in melanoma (unfavourable), prostate cancer (unfavourable) and renal cancer (unfavourable).
Melanoma p<0.001
Prostate cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA050975

GENE INFORMATION

Gene name

 SRSF4 (HGNC Symbol)

Synonyms

 SFRS4, SRP75

Description

 Serine/arginine-rich splicing factor 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the arginine/serine-rich splicing factor family. The encoded protein likely functions in mRNA processing. [provided by RefSeq, Feb 2009]

Chromosome

 1

Cytoband

 p35.3

Chromosome location (bp)

 29147743 - 29181987

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116350 (version 83.38)

Entrez gene

 6429

UniProt

 Q08170 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08170

Antibodypedia

 SRSF4 antibodies

PROTEIN BROWSER
SRSF4-001
SRSF4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRSF4-001
ENSP00000362900
ENST00000373795
Q08170 [Direct mapping]
Serine/arginine-rich splicing factor 4
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0031124 [mRNA 3'-end processing]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:1990825 [sequence-specific mRNA binding]
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 494 aa
56.7 kDa 		No 0
SRSF4-002
ENSP00000485813
ENST00000466448
A0A0D9SEM4 [Direct mapping]
Serine/arginine-rich-splicing factor 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
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 378 aa
43.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.