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Moderate to strong nuclear immunoreactivity was observed in most cancer tissues. Several renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
HDAC1 (HGNC Symbol)
Synonyms
GON-10, HD1, RPD3L1
Description
Histone deacetylase 1 (HGNC Symbol)
Entrez gene summary
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000278 [mitotic cell cycle] GO:0000785 [chromatin] GO:0000790 [nuclear chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001106 [RNA polymerase II transcription corepressor activity] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006325 [chromatin organization] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006476 [protein deacetylation] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0007596 [blood coagulation] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell proliferation] GO:0009913 [epidermal cell differentiation] GO:0010467 [gene expression] GO:0010629 [negative regulation of gene expression] GO:0010870 [positive regulation of receptor biosynthetic process] GO:0016032 [viral process] GO:0016568 [chromatin modification] GO:0016575 [histone deacetylation] GO:0016580 [Sin3 complex] GO:0016581 [NuRD complex] GO:0019213 [deacetylase activity] GO:0019899 [enzyme binding] GO:0031492 [nucleosomal DNA binding] GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)] GO:0032922 [circadian regulation of gene expression] GO:0033558 [protein deacetylase activity] GO:0033613 [activating transcription factor binding] GO:0040029 [regulation of gene expression, epigenetic] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0042733 [embryonic digit morphogenesis] GO:0042826 [histone deacetylase binding] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043922 [negative regulation by host of viral transcription] GO:0044212 [transcription regulatory region DNA binding] GO:0045786 [negative regulation of cell cycle] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0047485 [protein N-terminus binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0051059 [NF-kappaB binding] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0060789 [hair follicle placode formation] GO:0061029 [eyelid development in camera-type eye] GO:0061198 [fungiform papilla formation] GO:0070491 [repressing transcription factor binding] GO:0070932 [histone H3 deacetylation] GO:0070933 [histone H4 deacetylation]