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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SFPQ
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SFPQ

Gene description

Splicing factor proline/glutamine-rich

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA047513 , HPA054689 , CAB009886
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PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable) and breast cancer (favourable).
Liver cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY

HPA047513
HPA054689
CAB009886

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues displayed strong nuclear staining.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues showed strong nuclear positivity.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate nuclear immunoreactivity was observed in cancer tissues.

GENE INFORMATION

Gene name

SFPQ (HGNC Symbol)

Synonyms

PPP1R140, PSF

Description

Splicing factor proline/glutamine-rich (HGNC Symbol)

Entrez gene summary

Chromosome

1

Cytoband

p34.3

Chromosome location (bp)

35176378 - 35193148

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116560 (version 83.38)

Entrez gene

6421

UniProt

P23246 (UniProt - Evidence at protein level)

neXtProt

NX_P23246

Antibodypedia

SFPQ antibodies

PROTEIN BROWSER

SFPQ-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SFPQ-001
ENSP00000349748
ENST00000357214
P23246 [Direct mapping]
Splicing factor, proline- and glutamine-rich
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Yet undefined DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000166 [nucleotide binding]
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0003676 [nucleic acid binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008380 [RNA splicing]
GO:0016363 [nuclear matrix]
GO:0042382 [paraspeckles]
GO:0042752 [regulation of circadian rhythm]
GO:0042754 [negative regulation of circadian rhythm]
GO:0042826 [histone deacetylase binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045876 [positive regulation of sister chromatid cohesion]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048511 [rhythmic process]
GO:0051276 [chromosome organization]
GO:0051726 [regulation of cell cycle]
GO:0070932 [histone H3 deacetylation]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:1902177 [positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
Show all
707 aa
76.1 kDa
No 0

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