Expression of SFPQ in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene nameⁱ Gene name according to HGNC.	SFPQ
Gene descriptionⁱ Gene description according to HGNC.	Splicing factor proline/glutamine-rich
Protein classⁱ Protein class the gene product belongs to according to selected gene lists. List of protein classes.	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localizationⁱ Protein localization predicted from several bioinformatic algorithms. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcribed from this gene as defined by Ensembl.	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryⁱ

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidenceⁱ

Evidence at protein level

Protein expression
normal tissueⁱ

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability descriptionⁱ Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.	Antibody staining mainly consistent with RNA expression data.
Reliability scoreⁱ Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data. Read more	Supported based on 3 antibodies. HPA047513 , HPA054689 , CAB009886
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PROGNOSTIC SUMMARYⁱ Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Prognostic marker in liver cancer (unfavourable) and breast cancer (favourable).
Liver cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEWⁱ

TCGA datasetⁱ
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

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RNA cancer category: Expressed in all

PROTEIN EXPRESSIONⁱ

STAINING SUMMARYⁱ

HPA047513	HPA054689	CAB009886

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	SFPQ (HGNC Symbol)
Synonyms	PPP1R140, PSF
Description	Splicing factor proline/glutamine-rich (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p34.3
Chromosome location (bp)	35176378 - 35193148
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116560 (version 83.38)
Entrez gene	6421
UniProt	P23246 (UniProt - Evidence at protein level)
neXtProt	NX_P23246
Antibodypedia	SFPQ antibodies

PROTEIN BROWSERⁱ

SFPQ-001

PROTEIN INFORMATIONⁱ

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SFPQ-001
ENSP00000349748
ENST00000357214

P23246 [Direct mapping]
Splicing factor, proline- and glutamine-rich

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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Yet undefined DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000166 [nucleotide binding]
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0003676 [nucleic acid binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008380 [RNA splicing]
GO:0016363 [nuclear matrix]
GO:0042382 [paraspeckles]
GO:0042752 [regulation of circadian rhythm]
GO:0042754 [negative regulation of circadian rhythm]
GO:0042826 [histone deacetylase binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045876 [positive regulation of sister chromatid cohesion]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048511 [rhythmic process]
GO:0051276 [chromosome organization]
GO:0051726 [regulation of cell cycle]
GO:0070932 [histone H3 deacetylation]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:1902177 [positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]

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707 aa
76.1 kDa