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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SFPQ
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

SFPQ

Gene description

Splicing factor proline/glutamine-rich

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA047513 , HPA054689 , CAB009886
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

SFPQ (HGNC Symbol)

Synonyms

PPP1R140, PSF

Description

Splicing factor proline/glutamine-rich (HGNC Symbol)

Entrez gene summary

Chromosome

1

Cytoband

p34.3

Chromosome location (bp)

35176378 - 35193148

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116560 (version 83.38)

Entrez gene

6421

UniProt

P23246 (UniProt - Evidence at protein level)

neXtProt

NX_P23246

Antibodypedia

SFPQ antibodies

PROTEIN BROWSER

SFPQ-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SFPQ-001
ENSP00000349748
ENST00000357214
P23246 [Direct mapping]
Splicing factor, proline- and glutamine-rich
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Yet undefined DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000166 [nucleotide binding]
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0003676 [nucleic acid binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008380 [RNA splicing]
GO:0016363 [nuclear matrix]
GO:0042382 [paraspeckles]
GO:0042752 [regulation of circadian rhythm]
GO:0042754 [negative regulation of circadian rhythm]
GO:0042826 [histone deacetylase binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045876 [positive regulation of sister chromatid cohesion]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048511 [rhythmic process]
GO:0051276 [chromosome organization]
GO:0051726 [regulation of cell cycle]
GO:0070932 [histone H3 deacetylation]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:1902177 [positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
Show all
707 aa
76.1 kDa
No 0

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