Expression of GON4L in cancer - Summary - The Human Protein Atlas

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GON4L

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GON4L
Gene description	Gon-4-like (C. elegans)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 1 antibody. HPA006986
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA006986

GENE INFORMATION
Gene name	GON4L (HGNC Symbol)
Synonyms	FLJ20203, GON-4, GON4
Description	Gon-4-like (C. elegans) (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q22
Chromosome location (bp)	155749662 - 155859400
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116580 (version 83.38)
Entrez gene	54856
UniProt	Q3T8J9 (UniProt - Evidence at protein level)
neXtProt	NX_Q3T8J9
Antibodypedia	GON4L antibodies

PROTEIN BROWSER

GON4L-001	GON4L-018	GON4L-019	GON4L-201	GON4L-202	GON4L-203	GON4L-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GON4L-001 ENSP00000354322 ENST00000361040	Q3T8J9 [Direct mapping] GON-4-like protein Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	1529 aa 169.1 kDa	No	0
GON4L-018 ENSP00000271883 ENST00000271883	Q3T8J9 [Direct mapping] GON-4-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	2240 aa 248.5 kDa	No	0
GON4L-019 ENSP00000396117 ENST00000437809	Q3T8J9 [Direct mapping] GON-4-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	2240 aa 248.5 kDa	No	0
GON4L-201 ENSP00000357315 ENST00000368331	Q3T8J9 [Direct mapping] GON-4-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	2241 aa 248.6 kDa	No	0
GON4L-202 ENSP00000483100 ENST00000615926	Q3T8J9 [Direct mapping] GON-4-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	2241 aa 248.6 kDa	No	0
GON4L-203 ENSP00000481460 ENST00000620426	A4PB68 [Direct mapping] GON-4-like protein; YY1AP-related protein2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		970 aa 109.8 kDa	No	0
GON4L-204 ENSP00000478593 ENST00000622608	A0A087WUE6 [Direct mapping] GON-4-like protein Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		1542 aa 170.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.