Cell atlas - FBXO6 - The Human Protein Atlas

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FBXO6

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	FBXO6
Gene description	F-box protein 6
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	FBXO6 (HGNC Symbol)
Synonyms	FBG2, FBS2, FBX6, Fbx6b
Description	F-box protein 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.22
Chromosome location (bp)	11664124 - 11674354
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116663 (version 83.38)
Entrez gene	26270
UniProt	Q9NRD1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRD1
Antibodypedia	FBXO6 antibodies

PROTEIN BROWSER

FBXO6-001	FBXO6-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBXO6-001 ENSP00000365944 ENST00000376753	Q9NRD1 [Direct mapping] F-box only protein 6 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000077 [DNA damage checkpoint] GO:0001948 [glycoprotein binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006508 [proteolysis] GO:0006516 [glycoprotein catabolic process] GO:0006986 [response to unfolded protein] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0030246 [carbohydrate binding] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0044322 [endoplasmic reticulum quality control compartment] GO:0061630 [ubiquitin protein ligase activity] Show all	293 aa 33.9 kDa	No	0
FBXO6-003 ENSP00000388781 ENST00000449067	J3KQ72 [Direct mapping] F-box only protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	249 aa 28.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.