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FBXO6

GENERAL INFORMATION

Gene name

 FBXO6

Gene description

 F-box protein 6

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA051175
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (favourable) and ovarian cancer (favourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051175

GENE INFORMATION

Gene name

 FBXO6 (HGNC Symbol)

Synonyms

 FBG2, FBS2, FBX6, Fbx6b

Description

 F-box protein 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.22

Chromosome location (bp)

 11664124 - 11674354

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116663 (version 83.38)

Entrez gene

 26270

UniProt

 Q9NRD1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NRD1

Antibodypedia

 FBXO6 antibodies

PROTEIN BROWSER
FBXO6-001
FBXO6-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FBXO6-001
ENSP00000365944
ENST00000376753
Q9NRD1 [Direct mapping]
F-box only protein 6
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000077 [DNA damage checkpoint]
GO:0001948 [glycoprotein binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006508 [proteolysis]
GO:0006516 [glycoprotein catabolic process]
GO:0006986 [response to unfolded protein]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0030246 [carbohydrate binding]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0044322 [endoplasmic reticulum quality control compartment]
GO:0061630 [ubiquitin protein ligase activity]
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 293 aa
33.9 kDa 		No 0
FBXO6-003
ENSP00000388781
ENST00000449067
J3KQ72 [Direct mapping]
F-box only protein 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 249 aa
28.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.