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MAD2L2

GENERAL INFORMATION

Gene name

 MAD2L2

Gene description

 MAD2 mitotic arrest deficient-like 2 (yeast)

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB008110
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB008110

GENE INFORMATION

Gene name

 MAD2L2 (HGNC Symbol)

Synonyms

 MAD2B, POLZ2, REV7

Description

 MAD2 mitotic arrest deficient-like 2 (yeast) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.22

Chromosome location (bp)

 11674480 - 11691650

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116670 (version 83.38)

Entrez gene

 10459

UniProt

 Q9UI95 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UI95

Antibodypedia

 MAD2L2 antibodies

PROTEIN BROWSER
MAD2L2-001
MAD2L2-002
MAD2L2-003
MAD2L2-004
MAD2L2-006
MAD2L2-007
MAD2L2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAD2L2-001
ENSP00000235310
ENST00000235310
Q9UI95 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD2B
A0A024R4I4 [Target identity:100%; Query identity:100%]
MAD2 mitotic arrest deficient-like 2 (Yeast), isoform CRA_a
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001558 [regulation of cell growth]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0007015 [actin filament organization]
GO:0007067 [mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008432 [JUN kinase binding]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016035 [zeta DNA polymerase complex]
GO:0019985 [translesion synthesis]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042276 [error-prone translesion synthesis]
GO:0042772 [DNA damage response, signal transduction resulting in transcription]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051301 [cell division]
GO:0060564 [negative regulation of APC-Cdc20 complex activity]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
GO:2000678 [negative regulation of transcription regulatory region DNA binding]
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 211 aa
24.3 kDa 		No 0
MAD2L2-002
ENSP00000365857
ENST00000376669
B1AK44 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD2B
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 224 aa
25.7 kDa 		No 0
MAD2L2-003
ENSP00000365855
ENST00000376667
Q9UI95 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD2B
A0A024R4I4 [Target identity:100%; Query identity:100%]
MAD2 mitotic arrest deficient-like 2 (Yeast), isoform CRA_a
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001558 [regulation of cell growth]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0007015 [actin filament organization]
GO:0007067 [mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008432 [JUN kinase binding]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016035 [zeta DNA polymerase complex]
GO:0019985 [translesion synthesis]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042276 [error-prone translesion synthesis]
GO:0042772 [DNA damage response, signal transduction resulting in transcription]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051301 [cell division]
GO:0060564 [negative regulation of APC-Cdc20 complex activity]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
GO:2000678 [negative regulation of transcription regulatory region DNA binding]
Show all
 211 aa
24.3 kDa 		No 0
MAD2L2-004
ENSP00000365860
ENST00000376672
B1AK44 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD2B
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 224 aa
25.7 kDa 		No 0
MAD2L2-006
ENSP00000400982
ENST00000456915
B1AK45 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD2B
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 167 aa
19.1 kDa 		No 0
MAD2L2-007
ENSP00000411807
ENST00000445656
B1AK43 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD2B
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   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 198 aa
21.9 kDa 		No 0
MAD2L2-201
ENSP00000365882
ENST00000376692
Q9UI95 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD2B
A0A024R4I4 [Target identity:100%; Query identity:100%]
MAD2 mitotic arrest deficient-like 2 (Yeast), isoform CRA_a
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001558 [regulation of cell growth]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0007015 [actin filament organization]
GO:0007067 [mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008432 [JUN kinase binding]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016035 [zeta DNA polymerase complex]
GO:0019985 [translesion synthesis]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042276 [error-prone translesion synthesis]
GO:0042772 [DNA damage response, signal transduction resulting in transcription]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051301 [cell division]
GO:0060564 [negative regulation of APC-Cdc20 complex activity]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
GO:2000678 [negative regulation of transcription regulatory region DNA binding]
Show all
 211 aa
24.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.