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The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. [provided by RefSeq, Jul 2008]
THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001558 [regulation of cell growth] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005680 [anaphase-promoting complex] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0006351 [transcription, DNA-templated] GO:0007015 [actin filament organization] GO:0007067 [mitotic nuclear division] GO:0007094 [mitotic spindle assembly checkpoint] GO:0008432 [JUN kinase binding] GO:0010719 [negative regulation of epithelial to mesenchymal transition] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016035 [zeta DNA polymerase complex] GO:0019985 [translesion synthesis] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0042177 [negative regulation of protein catabolic process] GO:0042276 [error-prone translesion synthesis] GO:0042772 [DNA damage response, signal transduction resulting in transcription] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0051301 [cell division] GO:0060564 [negative regulation of APC-Cdc20 complex activity] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin] GO:2000678 [negative regulation of transcription regulatory region DNA binding]
THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001558 [regulation of cell growth] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005680 [anaphase-promoting complex] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0006351 [transcription, DNA-templated] GO:0007015 [actin filament organization] GO:0007067 [mitotic nuclear division] GO:0007094 [mitotic spindle assembly checkpoint] GO:0008432 [JUN kinase binding] GO:0010719 [negative regulation of epithelial to mesenchymal transition] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016035 [zeta DNA polymerase complex] GO:0019985 [translesion synthesis] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0042177 [negative regulation of protein catabolic process] GO:0042276 [error-prone translesion synthesis] GO:0042772 [DNA damage response, signal transduction resulting in transcription] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0051301 [cell division] GO:0060564 [negative regulation of APC-Cdc20 complex activity] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin] GO:2000678 [negative regulation of transcription regulatory region DNA binding]
THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001558 [regulation of cell growth] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005680 [anaphase-promoting complex] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0006351 [transcription, DNA-templated] GO:0007015 [actin filament organization] GO:0007067 [mitotic nuclear division] GO:0007094 [mitotic spindle assembly checkpoint] GO:0008432 [JUN kinase binding] GO:0010719 [negative regulation of epithelial to mesenchymal transition] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016035 [zeta DNA polymerase complex] GO:0019985 [translesion synthesis] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0042177 [negative regulation of protein catabolic process] GO:0042276 [error-prone translesion synthesis] GO:0042772 [DNA damage response, signal transduction resulting in transcription] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0051301 [cell division] GO:0060564 [negative regulation of APC-Cdc20 complex activity] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin] GO:2000678 [negative regulation of transcription regulatory region DNA binding]
