Expression of MIIP in cancer - Summary - The Human Protein Atlas

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MIIP

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MIIP
Gene description	Migration and invasion inhibitory protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (HDLM-2)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a few tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA044948
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044948

GENE INFORMATION
Gene name	MIIP (HGNC Symbol)
Synonyms	FLJ12438, IIp45
Description	Migration and invasion inhibitory protein (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]
Chromosome	1
Cytoband	p36.22
Chromosome location (bp)	12019466 - 12032045
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116691 (version 83.38)
Entrez gene	60672
UniProt	Q5JXC2 (UniProt - Evidence at protein level)
neXtProt	NX_Q5JXC2
Antibodypedia	MIIP antibodies

PROTEIN BROWSER

MIIP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MIIP-001 ENSP00000235332 ENST00000235332	Q5JXC2 [Direct mapping] Migration and invasion-inhibitory protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	388 aa 42.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.