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NCF2

GENERAL INFORMATION

Gene name

 NCF2

Gene description

 Neutrophil cytosolic factor 2

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (A-431, U-2 OS)
HPA (normal tissue):Tissue enhanced (bone marrow)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 High expression in neutrophils and macrophages.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA002327 , HPA006040 , CAB022160
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002327
HPA006040
CAB022160

GENE INFORMATION

Gene name

 NCF2 (HGNC Symbol)

Synonyms

 NOXA2, p67phox

Description

 Neutrophil cytosolic factor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

Chromosome

 1

Cytoband

 q25.3

Chromosome location (bp)

 183555563 - 183590876

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116701 (version 83.38)

Entrez gene

 4688

UniProt

 P19878 (UniProt - Evidence at protein level)

neXtProt

 NX_P19878

Antibodypedia

 NCF2 antibodies

PROTEIN BROWSER
NCF2-001
NCF2-002
NCF2-004
NCF2-005
NCF2-201
NCF2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NCF2-001
ENSP00000356506
ENST00000367536
P19878 [Direct mapping]
Neutrophil cytosol factor 2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006801 [superoxide metabolic process]
GO:0006968 [cellular defense response]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0009055 [electron carrier activity]
GO:0032010 [phagolysosome]
GO:0042554 [superoxide anion generation]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0043020 [NADPH oxidase complex]
GO:0045087 [innate immune response]
GO:0045730 [respiratory burst]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0090382 [phagosome maturation]
Show all
 526 aa
59.8 kDa 		No 0
NCF2-002
ENSP00000356505
ENST00000367535
P19878 [Direct mapping]
Neutrophil cytosol factor 2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001669 [acrosomal vesicle]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006801 [superoxide metabolic process]
GO:0006968 [cellular defense response]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0009055 [electron carrier activity]
GO:0032010 [phagolysosome]
GO:0042554 [superoxide anion generation]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0043020 [NADPH oxidase complex]
GO:0045087 [innate immune response]
GO:0045730 [respiratory burst]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0090382 [phagosome maturation]
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 526 aa
59.8 kDa 		No 0
NCF2-004
ENSP00000406198
ENST00000419402
B1ALB7 [Direct mapping]
Neutrophil cytosol factor 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 143 aa
16.2 kDa 		No 0
NCF2-005
ENSP00000397228
ENST00000420553
B1ALB6 [Direct mapping]
Neutrophil cytosol factor 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 56 aa
6.7 kDa 		No 0
NCF2-201
ENSP00000399294
ENST00000413720
P19878 [Direct mapping]
Neutrophil cytosol factor 2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006801 [superoxide metabolic process]
GO:0006968 [cellular defense response]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0009055 [electron carrier activity]
GO:0032010 [phagolysosome]
GO:0042554 [superoxide anion generation]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0043020 [NADPH oxidase complex]
GO:0045087 [innate immune response]
GO:0045730 [respiratory burst]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0090382 [phagosome maturation]
Show all
 481 aa
54.4 kDa 		No 0
NCF2-202
ENSP00000407217
ENST00000418089
P19878 [Direct mapping]
Neutrophil cytosol factor 2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006801 [superoxide metabolic process]
GO:0006968 [cellular defense response]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0009055 [electron carrier activity]
GO:0032010 [phagolysosome]
GO:0042554 [superoxide anion generation]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0043020 [NADPH oxidase complex]
GO:0045087 [innate immune response]
GO:0045730 [respiratory burst]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0090382 [phagosome maturation]
Show all
 445 aa
50.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.