Several cases of malignant lymphomas displayed moderate to strong cytoplasmic staining. A few colorectal and urothelial cancers showed moderate nuclear staining. Other malignancies were weakly stained or negative.
Malignant cells were generally negative. Several cases of malignant lymphomas showed moderate cytoplasmic immunoreactivity.
CD2 (HGNC Symbol)
CD2 molecule (HGNC Symbol)
Entrez gene summary
CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]