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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CD2
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CD2

Gene description

CD2 molecule

Protein class

CD markers
FDA approved drug targets
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Group enriched (HDLM-2, MOLT-4)
HPA (normal tissue):Tissue enhanced (lymph node)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA003883 , CAB002430
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), endometrial cancer (favourable), melanoma (favourable), head and neck cancer (favourable), cervical cancer (favourable), breast cancer (favourable) and ovarian cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
Melanoma p<0.001
Head and neck cancer p<0.001
Cervical cancer p<0.001
Breast cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA003883
CAB002430

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of malignant lymphomas displayed moderate to strong cytoplasmic staining. A few colorectal and urothelial cancers showed moderate nuclear staining. Other malignancies were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant cells were generally negative. Several cases of malignant lymphomas showed moderate cytoplasmic immunoreactivity.

GENE INFORMATION

Gene name

CD2 (HGNC Symbol)

Synonyms

SRBC

Description

CD2 molecule (HGNC Symbol)

Entrez gene summary

CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]

Chromosome

1

Cytoband

p13.1

Chromosome location (bp)

116754385 - 116769228

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116824 (version 83.38)

Entrez gene

914

UniProt

P06729 (UniProt - Evidence at protein level)

neXtProt

NX_P06729

Antibodypedia

CD2 antibodies

PROTEIN BROWSER

CD2-001
CD2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD2-001
ENSP00000358490
ENST00000369478
P06729 [Direct mapping]
T-cell surface antigen CD2
Q53F96 [Target identity:100%; Query identity:100%]
CD2 antigen (P50), sheep red blood cell receptor; CD2 antigen (P50), sheep red blood cell receptor variant; cDNA, FLJ94184, highly similar to Homo sapiens CD2 antigen (p50), sheep red blood cell receptor (CD2), mRNA
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001766 [membrane raft polarization]
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006915 [apoptotic process]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009897 [external side of plasma membrane]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0030101 [natural killer cell activation]
GO:0030887 [positive regulation of myeloid dendritic cell activation]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0042110 [T cell activation]
GO:0042803 [protein homodimerization activity]
GO:0045580 [regulation of T cell differentiation]
GO:0046658 [anchored component of plasma membrane]
GO:0050900 [leukocyte migration]
GO:1902715 [positive regulation of interferon-gamma secretion]
GO:2000484 [positive regulation of interleukin-8 secretion]
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351 aa
39.4 kDa
Yes 1
CD2-002
ENSP00000358489
ENST00000369477
Q5JVN7 [Direct mapping]
T-cell surface antigen CD2
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
133 aa
15.3 kDa
Yes 0

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