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CD2

GENERAL INFORMATION

Gene name

 CD2

Gene description

 CD2 molecule

Protein class

 CD markers
FDA approved drug targets
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node)
GTEx:Tissue enhanced (small intestine, spleen)
FANTOM5:Tissue enhanced (lymph node, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA003883 , CAB002430
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, tonsil)

GENE INFORMATION

Gene name

 CD2 (HGNC Symbol)

Synonyms

 SRBC

Description

 CD2 molecule (HGNC Symbol)

Entrez gene summary

 CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]

Chromosome

 1

Cytoband

 p13.1

Chromosome location (bp)

 116754385 - 116769228

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116824 (version 83.38)

Entrez gene

 914

UniProt

 P06729 (UniProt - Evidence at protein level)

neXtProt

 NX_P06729

Antibodypedia

 CD2 antibodies

PROTEIN BROWSER
CD2-001
CD2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD2-001
ENSP00000358490
ENST00000369478
P06729 [Direct mapping]
T-cell surface antigen CD2
Q53F96 [Target identity:100%; Query identity:100%]
CD2 antigen (P50), sheep red blood cell receptor; CD2 antigen (P50), sheep red blood cell receptor variant; cDNA, FLJ94184, highly similar to Homo sapiens CD2 antigen (p50), sheep red blood cell receptor (CD2), mRNA
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001766 [membrane raft polarization]
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006915 [apoptotic process]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009897 [external side of plasma membrane]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0030101 [natural killer cell activation]
GO:0030887 [positive regulation of myeloid dendritic cell activation]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0042110 [T cell activation]
GO:0042803 [protein homodimerization activity]
GO:0045580 [regulation of T cell differentiation]
GO:0046658 [anchored component of plasma membrane]
GO:0050900 [leukocyte migration]
GO:1902715 [positive regulation of interferon-gamma secretion]
GO:2000484 [positive regulation of interleukin-8 secretion]
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 351 aa
39.4 kDa 		Yes 1
CD2-002
ENSP00000358489
ENST00000369477
Q5JVN7 [Direct mapping]
T-cell surface antigen CD2
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
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 133 aa
15.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.