Cell atlas - ADPRHL2 - The Human Protein Atlas

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ADPRHL2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ADPRHL2
Gene description	ADP-ribosylhydrolase like 2
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA027104 , HPA027141
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA027104	A-431	Nucleoplasm
HPA027104	U-2 OS	Nucleoplasm
HPA027104	U-2 OS	Nuclear bodies
HPA027104	U-251 MG	Nucleoplasm
HPA027141	A-431	Nucleoplasm
HPA027141	U-2 OS	Nucleoplasm
HPA027141	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	ADPRHL2 (HGNC Symbol)
Synonyms	ARH3, FLJ20446
Description	ADP-ribosylhydrolase like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009]
Chromosome	1
Cytoband	p34.3
Chromosome location (bp)	36088875 - 36093932
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116863 (version 83.38)
Entrez gene	54936
UniProt	Q9NX46 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NX46
Antibodypedia	ADPRHL2 antibodies

PROTEIN BROWSER

ADPRHL2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADPRHL2-001 ENSP00000362273 ENST00000373178	Q9NX46 [Direct mapping] Poly(ADP-ribose) glycohydrolase ARH3 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004649 [poly(ADP-ribose) glycohydrolase activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0008152 [metabolic process] GO:0046872 [metal ion binding] GO:0071451 [cellular response to superoxide] Show all	363 aa 38.9 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.