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MRPS15

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GENERAL INFORMATION

Gene name

 MRPS15

Gene description

 Mitochondrial ribosomal protein S15

Protein class

 Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the mitochondria.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (supported)

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA028100 , HPA067137
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the mitochondria.

Main location

 Mitochondria (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA028100 A-431 Nuclear membrane
Mitochondria
HPA028100 U-2 OS Nuclear membrane
Mitochondria
HPA028100 U-251 MG Nuclear membrane
HPA067137 U-2 OS Mitochondria
HPA067137 U-251 MG Nucleus
Nucleoli
Mitochondria

GENE INFORMATION

Gene name

 MRPS15 (HGNC Symbol)

Synonyms

 FLJ11564

Description

 Mitochondrial ribosomal protein S15 (HGNC Symbol)

Entrez gene summary

 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 15q and 19q. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p34.3

Chromosome location (bp)

 36455718 - 36464437

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116898 (version 83.38)

Entrez gene

 64960

UniProt

 P82914 (UniProt - Evidence at protein level)

neXtProt

 NX_P82914

Antibodypedia

 MRPS15 antibodies

PROTEIN BROWSER
MRPS15-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRPS15-001
ENSP00000362208
ENST00000373116
P82914 [Direct mapping]
28S ribosomal protein S15, mitochondrial
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Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005763 [mitochondrial small ribosomal subunit]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0031965 [nuclear membrane]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
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 257 aa
29.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.