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TBCE

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GENERAL INFORMATION

Gene name

 TBCE

Gene description

 Tubulin folding cofactor E

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 TBCE (HGNC Symbol)

Synonyms

 HRD, KCS, KCS1, pac2

Description

 Tubulin folding cofactor E (HGNC Symbol)

Entrez gene summary

 Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q42.3

Chromosome location (bp)

 235367360 - 235448968

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116957 (version 83.38)

Entrez gene

 6905

UniProt

 Q15813 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15813

Antibodypedia

 TBCE antibodies

PROTEIN BROWSER
TBCE-001
TBCE-201
TBCE-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TBCE-001
ENSP00000355560
ENST00000366601
Q15813 [Direct mapping]
Tubulin-specific chaperone E
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007023 [post-chaperonin tubulin folding pathway]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051087 [chaperone binding]
Show all
 527 aa
59.3 kDa 		No 0
TBCE-201
ENSP00000384571
ENST00000406207
Q15813 [Direct mapping]
Tubulin-specific chaperone E
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007023 [post-chaperonin tubulin folding pathway]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051087 [chaperone binding]
Show all
 527 aa
59.3 kDa 		No 0
TBCE-202
ENSP00000439170
ENST00000543662
Q15813 [Direct mapping]
Tubulin-specific chaperone E
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005840 [ribosome]
GO:0005874 [microtubule]
GO:0006412 [translation]
GO:0006457 [protein folding]
GO:0007023 [post-chaperonin tubulin folding pathway]
GO:0007409 [axonogenesis]
GO:0008344 [adult locomotory behavior]
GO:0009791 [post-embryonic development]
GO:0014889 [muscle atrophy]
GO:0044267 [cellular protein metabolic process]
GO:0048589 [developmental growth]
GO:0048936 [peripheral nervous system neuron axonogenesis]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051087 [chaperone binding]
Show all
 578 aa
64.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.