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TBCE

GENERAL INFORMATION

Gene name

 TBCE

Gene description

 Tubulin folding cofactor E

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA026552 , HPA026557
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and head and neck cancer (unfavourable).
Renal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA026552
HPA026557

GENE INFORMATION

Gene name

 TBCE (HGNC Symbol)

Synonyms

 HRD, KCS, KCS1, pac2

Description

 Tubulin folding cofactor E (HGNC Symbol)

Entrez gene summary

 Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q42.3

Chromosome location (bp)

 235367360 - 235448968

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116957 (version 83.38)

Entrez gene

 6905

UniProt

 Q15813 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15813

Antibodypedia

 TBCE antibodies

PROTEIN BROWSER
TBCE-001
TBCE-201
TBCE-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TBCE-001
ENSP00000355560
ENST00000366601
Q15813 [Direct mapping]
Tubulin-specific chaperone E
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007023 [post-chaperonin tubulin folding pathway]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051087 [chaperone binding]
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 527 aa
59.3 kDa 		No 0
TBCE-201
ENSP00000384571
ENST00000406207
Q15813 [Direct mapping]
Tubulin-specific chaperone E
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007023 [post-chaperonin tubulin folding pathway]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051087 [chaperone binding]
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 527 aa
59.3 kDa 		No 0
TBCE-202
ENSP00000439170
ENST00000543662
Q15813 [Direct mapping]
Tubulin-specific chaperone E
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Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005840 [ribosome]
GO:0005874 [microtubule]
GO:0006412 [translation]
GO:0006457 [protein folding]
GO:0007023 [post-chaperonin tubulin folding pathway]
GO:0007409 [axonogenesis]
GO:0008344 [adult locomotory behavior]
GO:0009791 [post-embryonic development]
GO:0014889 [muscle atrophy]
GO:0044267 [cellular protein metabolic process]
GO:0048589 [developmental growth]
GO:0048936 [peripheral nervous system neuron axonogenesis]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051087 [chaperone binding]
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 578 aa
64.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.